ISSN 10703284, Russian Journal of Coordination Chemistry, 2015, Vol. 41, No. 5, pp. 345–352. © Pleiades Publishing, Ltd., 2015.
Schiff bases and their complexes have a variety of
applications including biological, clinical and analyti
cal, and have been extensively studied over the past few
decades [1–3]. Schiff base metal complexes are very
popular due to their diverse chelating ability . They
play an important role in both synthetic and structural
research, because of their preparative accessibility and
structural diversity . Due to variable magnetic prop
erty and catalytic activity, they can also serve as efficient
models for the metalloproteins and enzymes [6, 7]. In
view of the interest involved in the Schiff base complex
es, many cobalt Schiff base complexes have been syn
thesized and characterized [8, 9]. We report herein the
synthesis and biological evaluation of Schiff base com
plexes of cobalt.
Materials, methods and measurements.
chemicals were purchased from Sigma Aldrich. Ele
mental analyses of the compounds were carried out us
ing the ElementarVario EL III CHN analyzer. The
FTIR spectra were recorded on a Shimadzu FTIR
spectrophotometer in the 4000–400 cm
UVVis spectra were recorded on an Elico SL 159 UV
Vis spectrophotometer. The molar conductance of the
complex was measured using a Systronics conductivity
bridge at room temperature in DMSO solution. The
thermal behavior of Co(III) complex was studied us
The article is published in the original.
ing PerkinElmer STA 6000 thermo analyzer. The anti
microbial activity of the ligand and its Co complex was
carried out by disc diffusion method. The Schiff base
ligand was prepared from salicylaldehyde and ethylene
diamine according to the reported procedure [10, 11].
The human cervical cancer cell line (HeLa) was ob
tained from National Centre for Cell Science
(NCCS), Pune and grown in Eagles Minimum Essen
tial Medium (EMEM) containing 10% fetal bovine
serum (FBS). All cells were maintained at 37
, 95% air and 100% relative humidity.
Synthesis of Co(III) complex (I).
The Schiff base
ligand (0.0328 g, 0.2 mmol) in ethanol (10 mL) was added
to a solution of CoCl
O (0.0237 g, 0.1 mmol) in eth
anol (10 mL), and the mixture was heated under reflux
for 5 h. The product obtained was filtered, washed and
dried. The yield was 67%, m.p. = 218
C, orange solid.
) 3380 s, 3420 s, 1634 s, 1448 w, 1386 w,
1298 w, 1154 w, 1123 w, 673 s, 598 m, 553 m, 548 m.
Xray determination of structure I.
APEX 2 Xray (threecircle) diffractometer was em
ployed for crystal screening, unit cell determination,
and data collection. The Xray radiation employed
was generated from a Mo sealed Xray tube
with a potential of 40 kV and a current
of 40 mA) fitted with a graphite monochromator in the
anal. calcd., %: C, 49.22; H, 5.46; N, 12.76,
Found, %: C, 49.22; H, 5.47; N, 12.76.
Synthesis, Structure, and Pharmacological Evaluation of Co(III)
Complex Containing Tridentate Schiff Base Ligand
S. Jone Kirubavathy
, R. Velmurugan
, R. Karvembu
, N. S. P. Bhuvanesh
, and S. Chitra
Department of Chemistry, Kongunadu Arts and Science College, Coimbatore, 641029 India
Department of Chemistry, National Institute of Technology, Tiruchirappalli, 620015 India
Department of Chemistry, Texas A&M University, College Station, TX 77842 USA
Department of Chemistry, P.S.G. R. Krishnammal College for Women, Coimbatore, 641004 India
Received October 16, 2014
A Co(III) Schiff base complex with the formula [Co(L)
) (L = monoanionic triden
tate Schiff base ligand derived from salicylaldehyde and ethylene diamine) has been synthesized and charac
terized by elemental analysis and spectroscopic techniques. The structure of
was confirmed by single crystal
Xray diffraction studies (CIF file CCDC no. 1009967), which showed the presence of two Schiff base mol
ecules in an octahedral fashion. The complex has been screened for its in vitro antibacterial and anticancer
was found to be more active in antimicrobial and anticancer activity than the ligand.