Nine 3-acetylcoumarins derivatives were synthesized and characterized via MS, 1H NMR, FT-IR, and UV–vis absorption spectra. The fluorescence behaviors of the compounds in dichloromethane solutions were observed. The minimum inhibitory concentration was observed for the nine title compounds and antibiotics, to evaluate their in vitro antibacterial activity against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), Escherichia coli (E. Coli ATCC 25922), and extended spectrum β lactamases E. coli (ESBLs-E. coli ATCC 35218). These results showed that the compound 2 exhibits the antibacterial activities to S. aureus.
Research on Chemical Intermediates – Springer Journals
Published: Oct 22, 2013
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