Electronic supplementary material The online version of this article (doi:10.1007/s11030-017-9738-7) contains supplementary material, which is available to authorized users. Rakesh Kumar email@example.com Bio-organic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India Laboratory of Organic Chemistry, Department of Pharmacology and Therapeutical Chemistry, Faculty of Pharmacy, University of Barcelona, Barcelona Science Park, Keywords Pyranopyrazole-1 · 4-Dihydropyridines · Baldiri Reixac 10-12, 08028 Barcelona, Spain Inotropic effect · Molecular docking · Structure–activity Drug Discovery Platform, Parc Cientíﬁc de Barcelona, Baldiri analysis · CYP450 inhibition · Microwave synthesis · SeO Reixac 10-12, 08028 Barcelona, Spain USEF Screening Platform, Centre of Research on Molecular Medicine and Chronic Diseases (CIMUS), Universidad de Santiago de Compostela (USC), Santiago de Compostela, Introduction Spain Systems Pharmacology, Research Program on Biomedical Calcium ions are essential in various physiological signal- Informatics (GRIB), IMIM Hospital del Mar Medical ing pathways. The movement of calcium ions across the cell Research Institute and University Pompeu Fabra, Doctor Aiguader 88 (PRBB), 08003 Barcelona, Catalonia, Spain occurs via the ligand-gated or voltage-gated calcium chan- 123 534 Mol Divers (2017) 21:533–546 nels, leading to increased/decreased intracellular calcium thesize a new class of pharmacologically active scaffolds levels generating various physiological responses . The by hybridizing
Molecular Diversity – Springer Journals
Published: Apr 25, 2017
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