Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked 1,4-dihydropyridines as potent positive inotropes

Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked... Electronic supplementary material The online version of this article (doi:10.1007/s11030-017-9738-7) contains supplementary material, which is available to authorized users. Rakesh Kumar Bio-organic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India Laboratory of Organic Chemistry, Department of Pharmacology and Therapeutical Chemistry, Faculty of Pharmacy, University of Barcelona, Barcelona Science Park, Keywords Pyranopyrazole-1 · 4-Dihydropyridines · Baldiri Reixac 10-12, 08028 Barcelona, Spain Inotropic effect · Molecular docking · Structure–activity Drug Discovery Platform, Parc Científic de Barcelona, Baldiri analysis · CYP450 inhibition · Microwave synthesis · SeO Reixac 10-12, 08028 Barcelona, Spain USEF Screening Platform, Centre of Research on Molecular Medicine and Chronic Diseases (CIMUS), Universidad de Santiago de Compostela (USC), Santiago de Compostela, Introduction Spain Systems Pharmacology, Research Program on Biomedical Calcium ions are essential in various physiological signal- Informatics (GRIB), IMIM Hospital del Mar Medical ing pathways. The movement of calcium ions across the cell Research Institute and University Pompeu Fabra, Doctor Aiguader 88 (PRBB), 08003 Barcelona, Catalonia, Spain occurs via the ligand-gated or voltage-gated calcium chan- 123 534 Mol Divers (2017) 21:533–546 nels, leading to increased/decreased intracellular calcium thesize a new class of pharmacologically active scaffolds levels generating various physiological responses [1]. The by hybridizing Molecular Diversity Springer Journals

Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked 1,4-dihydropyridines as potent positive inotropes

Loading next page...
Springer International Publishing
Copyright © 2017 by Springer International Publishing Switzerland
Life Sciences; Biochemistry, general; Organic Chemistry; Polymer Sciences; Pharmacy
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial