Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked 1,4-dihydropyridines as potent positive inotropes

Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked... Electronic supplementary material The online version of this article (doi:10.1007/s11030-017-9738-7) contains supplementary material, which is available to authorized users. Rakesh Kumar rakehskp@email.com Bio-organic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India Laboratory of Organic Chemistry, Department of Pharmacology and Therapeutical Chemistry, Faculty of Pharmacy, University of Barcelona, Barcelona Science Park, Keywords Pyranopyrazole-1 · 4-Dihydropyridines · Baldiri Reixac 10-12, 08028 Barcelona, Spain Inotropic effect · Molecular docking · Structure–activity Drug Discovery Platform, Parc Científic de Barcelona, Baldiri analysis · CYP450 inhibition · Microwave synthesis · SeO Reixac 10-12, 08028 Barcelona, Spain USEF Screening Platform, Centre of Research on Molecular Medicine and Chronic Diseases (CIMUS), Universidad de Santiago de Compostela (USC), Santiago de Compostela, Introduction Spain Systems Pharmacology, Research Program on Biomedical Calcium ions are essential in various physiological signal- Informatics (GRIB), IMIM Hospital del Mar Medical ing pathways. The movement of calcium ions across the cell Research Institute and University Pompeu Fabra, Doctor Aiguader 88 (PRBB), 08003 Barcelona, Catalonia, Spain occurs via the ligand-gated or voltage-gated calcium chan- 123 534 Mol Divers (2017) 21:533–546 nels, leading to increased/decreased intracellular calcium thesize a new class of pharmacologically active scaffolds levels generating various physiological responses [1]. The by hybridizing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Diversity Springer Journals

Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked 1,4-dihydropyridines as potent positive inotropes

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing Switzerland
Subject
Life Sciences; Biochemistry, general; Organic Chemistry; Polymer Sciences; Pharmacy
ISSN
1381-1991
eISSN
1573-501X
D.O.I.
10.1007/s11030-017-9738-7
Publisher site
See Article on Publisher Site

Abstract

Electronic supplementary material The online version of this article (doi:10.1007/s11030-017-9738-7) contains supplementary material, which is available to authorized users. Rakesh Kumar rakehskp@email.com Bio-organic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India Laboratory of Organic Chemistry, Department of Pharmacology and Therapeutical Chemistry, Faculty of Pharmacy, University of Barcelona, Barcelona Science Park, Keywords Pyranopyrazole-1 · 4-Dihydropyridines · Baldiri Reixac 10-12, 08028 Barcelona, Spain Inotropic effect · Molecular docking · Structure–activity Drug Discovery Platform, Parc Científic de Barcelona, Baldiri analysis · CYP450 inhibition · Microwave synthesis · SeO Reixac 10-12, 08028 Barcelona, Spain USEF Screening Platform, Centre of Research on Molecular Medicine and Chronic Diseases (CIMUS), Universidad de Santiago de Compostela (USC), Santiago de Compostela, Introduction Spain Systems Pharmacology, Research Program on Biomedical Calcium ions are essential in various physiological signal- Informatics (GRIB), IMIM Hospital del Mar Medical ing pathways. The movement of calcium ions across the cell Research Institute and University Pompeu Fabra, Doctor Aiguader 88 (PRBB), 08003 Barcelona, Catalonia, Spain occurs via the ligand-gated or voltage-gated calcium chan- 123 534 Mol Divers (2017) 21:533–546 nels, leading to increased/decreased intracellular calcium thesize a new class of pharmacologically active scaffolds levels generating various physiological responses [1]. The by hybridizing

Journal

Molecular DiversitySpringer Journals

Published: Apr 25, 2017

References

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