Synthetic efforts toward the potential bacterial peptide deformylase inhibitor fumimycin are reported. The synthetic approach features a tandem Friedel–Crafts alkylation/lactonization access as key reaction to the α, α-disubstituted amino acid unit, and results in the synthesis of an advanced racemic intermediate with an Z configuration propenyl group starting from vanillin with 18 % total yield in five steps.
Research on Chemical Intermediates – Springer Journals
Published: Sep 26, 2012
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