Synthesis of quinazoline derivatives as antimicrobial agents in the presence of MNP-TA Si OW OH MNP NH OO (0.1 g, 5 mol%) R NH + 2 O o COOH Solvent free, 80 C N 4a-4j Keywords Quinazolinone · Synthesis · Antimicrobial · Antifungal Introduction Quinazolinones are remarkable in medicinal chemistry, Electronic supplementary material The online version of this because of their wide range of biological activity for exam- article (https ://doi.org/10.1007/s1373 8-018-1337-8) contains ple hypnotic, sedative, anti-convulsant, anti-tussive, anti-dia- supplementary material, which is available to authorized users. betic, anti-tumor, antibacterial, antifungal, antiinflammatory, antimalarial and antiviral [1–6]. * Soghra Khabnadideh email@example.com Numerous bioactive natural products such as Febrifugine has quinazolinone moieties with potential biological activity Pharmaceutical Sciences Research Center, Shiraz University . Febrifugine is the active principle extracted from a Chi- of Medical Sciences, Shiraz, Iran nese medicinal plant, chang shan (Dichroa febrifuga Lour), Department of Parasitology and Mycology, Faculty that has been prescribed in traditional Chinese medicine as of Medicine, Shiraz University of Medical Sciences, Shiraz, an antimalarial agent . Febrifugine halogenated derivative Iran Vol.:(0123456789) 1 3 1458 Journal of the Iranian Chemical Society (2018) 15:1457–1466 (Halofuginone) is also specifically shown to be an effective and still the catalyst stay in it in some cases. We introduced
Journal of the Iranian Chemical Society – Springer Journals
Published: May 29, 2018
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