Synthesis of some acylated 2-pyrazoline and chalcone
Received: 23 October 2012 / Accepted: 8 January 2013 / Published online: 29 January 2013
Ó Springer Science+Business Media Dordrecht 2013
Abstract a-Haloesters containing the chalcone structure and a-haloamides con-
taining the pyrazoline ring have been synthesized by reaction of substituted hydroxy
chalcones and pyrazoline derivatives (prepared as reported elsewhere; J Chem
8(4):1574–1581, 2011) with chloroacetyl chloride in dry THF in the presence of
N. The structures of the synthesized compounds were conﬁrmed by IR,
H NMR, and (for some compounds)
C NMR spectroscopy.
Keywords Aromatic aldehydes Á Chalcones Á Pyrazolines Á Benzofurans Á
a-Haloamides Á a-Haloesters
The pyrazoline function is stable, which has encouraged chemists to utilize the
structure for synthesis of new bioactive pyroline derivatives with such biological
properties as antibacterial [1–3], antifungal , antitumor , analgesic , and
cytotoxic  activity.
Benzofuran derivatives are an interesting class of heterocyclic compounds. Many
benzofuran derivatives have been used as antioxidants, brightening agents,
ﬂuorescent sensors , and in other ﬁelds of chemistry . Many natural products
are benzofuran derivatives, including bergapten, nodakenetin xanthotoxin, and
khellin (Fig. 1).
Compounds in which the benzofuran and pyrazoline rings are combined are more
effective against multidrug-resistant bacteria [10, 11]. This encouraged us to study
benzofuran-substituted pyrazoline and chalcone derivatives.
D. Cos¸kun (&) Á M. Ahmedzade
Department of Chemistry, Faculty of Science, Firat University, 23119 Elazig, Turkey
Res Chem Intermed (2014) 40:1193–1199