Optimization of a green approach to the synthesis of pyrano[2,3-c]pyrazoles based on the one-pot, four-component condensation via a domino Knoevenagel/Michael/cyclization sequence was investigated. This method involved the evaluation of the activity of several ionic liquids (ILs) in various solvents. This one-pot, four-component reaction revealed simplicity, higher yield and lower toxicity advantages over a corresponding three-component method. The effect of reaction parameters including the type and amount of catalyst, type of solvent, reaction temperature and time were studied with respect to yield of pyrano[2,3-c]pyrazoles. Catalyst recyclability and time-saving aspects of the reaction suggest that this method presents real alternatives over conventional reaction protocols.
Research on Chemical Intermediates – Springer Journals
Published: Jul 20, 2016
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