Synthesis of pyran annulated heterocyclic scaffolds: a highly convenient protocol using dimethylamine

Synthesis of pyran annulated heterocyclic scaffolds: a highly convenient protocol using... A facile and rapid three-component synthesis of pharmaceutically diverse pyran annulated heterocycles has been developed via a one-pot condensation of aromatic aldehydes, malononitrile, and different enolizable C–H-activated acidic compounds in the presence of dimethylamine as a newer and effective organo-catalyst in ethanol under mild reaction conditions. Selectivity of various pyran derivatives depends on the structure of enolates. The present protocol has synthetic advantages of excellent yields in much shorter reaction times with no chromatography. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis of pyran annulated heterocyclic scaffolds: a highly convenient protocol using dimethylamine

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Publisher
Springer Netherlands
Copyright
Copyright © 2014 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-014-1873-5
Publisher site
See Article on Publisher Site

Abstract

A facile and rapid three-component synthesis of pharmaceutically diverse pyran annulated heterocycles has been developed via a one-pot condensation of aromatic aldehydes, malononitrile, and different enolizable C–H-activated acidic compounds in the presence of dimethylamine as a newer and effective organo-catalyst in ethanol under mild reaction conditions. Selectivity of various pyran derivatives depends on the structure of enolates. The present protocol has synthetic advantages of excellent yields in much shorter reaction times with no chromatography.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Dec 13, 2014

References

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