Synthesis of polysubstituted furans via a novel
and efﬁcient heterocyclization approach
Received: 23 August 2011 / Accepted: 22 February 2012 / Published online: 9 March 2012
Ó Springer Science+Business Media B.V. 2012
Abstract A new catalyst-free, one-pot synthesis of polysubstituted furans is reported.
A series of [4-(4-aryl)-5-(cyclohexylamino)-2-(pyridin-2-yl)furan-3-yl](pyridin-2-yl)-
methanones was synthesized via multicomponent reaction of 1,3-di(pyridin-2-yl)pro-
pane-1,3-dione, aryl aldehydes, and cyclohexyl isocyanide.
Keywords Polysubstituted furan Á Catalyst-free Á IMCR
Multicomponent reactions (MCRs) include a series of simultaneous multi bond-
forming reactions which enable construction of structurally diverse compounds
through combinatorial interactions between simple starting materials, leading to the
target products by one-pot operation [1, 2]. Simpliﬁed puriﬁcation of products
because of incorporation of all the starting substrates into the ﬁnal product, and the
possibility of preparing complex products starting from simple initial substrates in
one-step operation, are other advantages of MCRs [3, 4].
Furans are important intermediates for synthesis of oxygenated natural products
. Polysubstituted furans are among the most important heterocyclic compounds
with widespread occurrence in nature [5, 6]. The pharmacological and biological
S. Damavandi (&)
Department of Chemistry, Faculty of Sciences, University of Isfahan, 81746-73441 Isfahan, Iran
Department of Chemistry, Faculty of Science, Birjand University, Birjand, Iran
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
Res Chem Intermed (2012) 38:1969–1974