Makaram M. Said, Azza T. Taher, Hala B. El-Nassan , Eman A. El-Khouly Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt New S-acyl and S-alkylpyrimidinones were synthesized as cytotoxic agents. Compound 8g was the most potent cytotoxic on MCF-7 cell line. Compound 8g was potent and selective pim1 inhibitor. N O O N S 8g Cl Keywords Pyrimidine Antitumor activity MCF-7 HCT-116 pim1 Introduction Cancer is considered the second leading cause of death worldwide after cardiovascular diseases . In spite of the presence of a large number of chemotherapeutic agents, they cause severe side effects and development of resistance by cancer cells even against drugs developed by targeted therapy such as imitanib . Therefore, there is a continuous need for the development of novel molecules that can overcome cellular resistance. Since the introduction of 5-ﬂourouracil in the late 1950s as a potent anticancer agent, many uracil and thiouracil derivatives have been reported as cytotoxic agents . In addition, 4-aryl-5-cyanopyrimidinone derivatives were recently reported as cytotoxic agents [4–7]. In most of these derivatives, alkylation of the 2-thio group especially with alkylamino or acetanilide moieties (such as compounds I–IV, Fig. 1) was reported
Research on Chemical Intermediates – Springer Journals
Published: Mar 11, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud