Synthesis of novel 4-hydroxycarbazole derivatives and evaluation of their in vitro anti-inflammatory, anti-oxidant activities and molecular docking

Synthesis of novel 4-hydroxycarbazole derivatives and evaluation of their in vitro... Synthesis of novel 4-hydroxycarbazole derivatives 4a–q has been reported in good yields. The reaction involves O-alkylation of 4-hydroxycarbazole using methyl 5-bromovalerate results in 2, which on hydrolysis followed by coupling reaction with different primary and secondary amines leads to the formation of 4a–q. All the synthesized compounds 4a–q were characterized using IR, NMR and mass spectral analysis. The synthesized compounds 4a–q was screened for their in vitro anti-inflammatory and total anti-oxidant activity using albumin denaturation and phosphomolybdenum methods, respectively. Among the synthesized compounds, compounds 4h, 4j and 4q were found to show good anti-inflammatory activities against the standard drug diclofenac sodium. Similarly, compounds 4j, 4q and 4p showed very good anti-oxidant activities when compared with the standard drug ascorbic acid. Free energy of binding for all the synthesized compounds was calculated using AutoDock 1.5.4 against corticosteroid-binding globulin (PDB ID: 2V95) receptor. Among the synthesized compounds, compound 4j has shown a high binding energy value of −8.36 kcal/mol. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis of novel 4-hydroxycarbazole derivatives and evaluation of their in vitro anti-inflammatory, anti-oxidant activities and molecular docking

Loading next page...
 
/lp/springer_journal/synthesis-of-novel-4-hydroxycarbazole-derivatives-and-evaluation-of-P24WrIO0of
Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2831-1
Publisher site
See Article on Publisher Site

Abstract

Synthesis of novel 4-hydroxycarbazole derivatives 4a–q has been reported in good yields. The reaction involves O-alkylation of 4-hydroxycarbazole using methyl 5-bromovalerate results in 2, which on hydrolysis followed by coupling reaction with different primary and secondary amines leads to the formation of 4a–q. All the synthesized compounds 4a–q were characterized using IR, NMR and mass spectral analysis. The synthesized compounds 4a–q was screened for their in vitro anti-inflammatory and total anti-oxidant activity using albumin denaturation and phosphomolybdenum methods, respectively. Among the synthesized compounds, compounds 4h, 4j and 4q were found to show good anti-inflammatory activities against the standard drug diclofenac sodium. Similarly, compounds 4j, 4q and 4p showed very good anti-oxidant activities when compared with the standard drug ascorbic acid. Free energy of binding for all the synthesized compounds was calculated using AutoDock 1.5.4 against corticosteroid-binding globulin (PDB ID: 2V95) receptor. Among the synthesized compounds, compound 4j has shown a high binding energy value of −8.36 kcal/mol.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Dec 22, 2016

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off