Synthesis of novel 1,2,3-triazole-containing pyridine–pyrazole amide derivatives based on one-pot click reaction and their evaluation for potent nematicidal activity against Meloidogyne incognita

Synthesis of novel 1,2,3-triazole-containing pyridine–pyrazole amide derivatives based on... In order to find a novel, leading nematicide compound, a series of pyridine–pyrazole amide derivatives containing 1,2,3-triazoles were synthesized via click chemistry in a one-pot reaction. Their structures were characterized by proton nuclear magnetic resonance ( 1H NMR), 13C NMR, 19F NMR and high-resolution mass spectrometry (HRMS). Preliminary bioassays showed that most of the synthesized compounds exhibited good inhibitory activity in vivo against Meloidogyne incognita at 25 mg L−1. Among the tested compounds, 3a, 3e, 3f, 3g, 3j, 3m, 3q, 3s, 3t, 3v and 3w exhibited 100 % inhibition rates. Moreover, 3k displayed a 92.4 % inhibitory activity at 10 mg L−1. This investigation suggested that this pyridine–pyrazole amide containing a 1,2,3-triazole scaffold could be further optimized to explore novel, high-bioactivity nematicidal leads. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis of novel 1,2,3-triazole-containing pyridine–pyrazole amide derivatives based on one-pot click reaction and their evaluation for potent nematicidal activity against Meloidogyne incognita

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Publisher
Springer Netherlands
Copyright
Copyright © 2015 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-015-2381-y
Publisher site
See Article on Publisher Site

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