Newer tetrahydropyridine chalcones were synthesized and tested for their antioxidant and anticancer activity. These molecules showed significant anticancer activity at IC50 < 50 μM in human cancer cell lines such as A549 (lung adenocarcinoma), HepG2 (hepatocellular liver carcinoma), HeLa (cervical cancer), HCT-116 (colon carcinoma cells), MCF-7 (breast cancer cell line), and MDA MB 231 (breast cancer cells) cancer cells. The test compounds significantly inhibited cancer cell migrations in scratch wound assay for angiogenesis. Further, the test compounds bearing naphthalene substituents on the main ring showed in vitro antioxidant activity at <100 µM by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation, superoxide radical scavenging, O-phenonthroline, and lipid peroxidation assays. In conclusion, two test compounds bearing naphthalene substitutions exhibited potent anticancer activity that could be attributed to their ability to induce apoptosis, inhibit cancer cell migrations, provide anti-angiogenic properties, and also partly by reducing oxidative stress by scavenging free radicals.
Research on Chemical Intermediates – Springer Journals
Published: Sep 10, 2015
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera