New series of 8-((5-((1 H -indol-3-yl)methyl)-1,3,4-oxadiazol-2-yl)methoxy)quinolines were synthesized using T3P ® as a green catalyst and screened for their cytotoxic and antimitotic potential. The most active 8-((5-(3-(1 H -indol-3-yl)propyl)-1,3,4-oxadiazol-2-yl)methoxy)quinoline 3d , displayed good binding interactions with the colchicine binding cavity of microtubule.(Figure not available: see fulltext.)
Research on Chemical Intermediates – Springer Journals
Published: Jan 14, 2016
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