Russian Journal of Applied Chemistry, 2009, Vol. 82, No. 10, pp. 1867−1870.
Pleiades Publishing, Ltd., 2009.
Original Russian Text V.G. Dudarev, A.A. Iozep, 2009, published in Zhurnal Prikladnoi Khimii, 2009, Vol. 82, No. 10, pp. 1715−1718.
AND INDUSTRIAL ORGANIC CHEMISTRY
Synthesis of Hydrazide, Azide and Substututed Amides
V. G. Dudarev and A. A. Iozep
St. Petersburg State Chemical-Pharmaceutical Academy, St. Petersburg, Russia
Received April 29, 2009
Abstract—Synthesis of hydrazide, azide and substututed amides of carboxymethylchitin is reported. Stability of
azides in aqueous solution and their acylating ability in the reactions with aromatic amines are studied.
Chitin and its derivatives possess important properties
and are used as auxiliary and biologically active
compounds in medicine, pharmacy and cosmetics [1, 2].
Insolubility in water restricts essentially chitin application
area; therefore modiﬁ cation of polymer with hydrophilic
groups is actual problem. Carboxymethylation of chitin
is a most studied process allowing synthesis of water-
soluble polysaccharide derivatives . Carboxyl groups