ISSN 1070-4272, Russian Journal of Applied Chemistry, 2016, Vol. 89, No. 8, pp. 1286−1291. © Pleiades Publishing, Ltd., 2016.
Original Russian Text © M.V. Semenova, S.V. Osadchenko, Ya.O. Mezhuev, M.I. Shtil’man, I.N. Semenova,
2016, published in Zhurnal Prikladnoi Khimii, 2016,
Vol. 89, No. 8, pp. 1037−1042.
AND POLYMERIC MATERIALS
The development of new hydrogel-based materials
for medicobiological articles suitable for contact
with blood is largely restricted by such factors as low
mechanical strength of such materials, need for ensuring
high level of hemocompatibility, and possibility of
their reprocessing in combination with the minimum
possible biodegradation rate [1, 2]. The biodegradation
rate of linear single-backbone water-soluble polymers
is determined by the rate of their dissolution in
biological ﬂ uids . The biodegradability of water-
soluble polymers is traditionally suppressed by cross-
linking, but processing of the cross-linked products into
articles of required shape involves certain problems.
Furthermore, cross-linking of water-soluble polymers
limits the possibility of puriﬁ cation of the resulting
nonmelting and nonﬂ owing materials to remove low-
molecular-mass cross-linking agents, which are often
very toxic [4, 5].
The products of branching of polyvinyl alcohol with
epichlorohydrin in alkaline solution, whose formation
precedes the formation of the cross-linked polymer, are
of much interest in this respect [5–7]:
The resulting branched polymers dissolve in boiling
water and show only limited swelling in water at
temperatures close to the physiological temperature.
These properties allow, on the one hand, the polymers
Branched polyvinyl alcohol
to be processed from aqueous solutions and, on the other
hand, the biodegradation to be suppressed. Furthermore,
even linear polyvinyl alcohol has high mechanical
strength [8, 9], which, as known, increases with an
Synthesis of Hemocompatible Materials
Based on Branched Polyvinyl Alcohol
M. V. Semenova, S. V. Osadchenko, Ya. O. Mezhuev*, M. I. Shtil’man, and I. N. Semenova
Mendeleev University of Chemical Technology of Russia, Miusskaya pl., 9, Moscow, 125047 Russia
Received August 23, 2016
Abstract—The possibility of modiﬁ cation of polyvinyl alcohol with epichlorohydrin was examined with the aim
of preparing hemocompatible materials exhibiting high mechanical density at limited swellability. The conditions
of modiﬁ cation and preparation of branched polyvinyl alcohol and of hemocompatible hydrogel systems with
improved operation properties were determined.