Synthesis of deuterium-enriched and fluorine-substituted plinabulin derivatives and evaluation of their antitumor activities

Synthesis of deuterium-enriched and fluorine-substituted plinabulin derivatives and evaluation of... Deuterium-enriched and fluorine-substituted compounds have been widely applied in drug discovery due to their advantages in the studies of clinical pharmacokinetics and metabolic profiles. Herein we synthesized a library of deuterated and fluorine-substituted plinabulin derivatives, and all 15 D- or F-compounds were characterized by MS, $$^{1}\hbox {H}$$ 1 H NMR and $$^{ 13}\hbox {C}\,\hbox {NMR}$$ 13 C NMR . Their antitumor activities were evaluated against human Jurkat T lymphocyte cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Diversity Springer Journals

Synthesis of deuterium-enriched and fluorine-substituted plinabulin derivatives and evaluation of their antitumor activities

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing Switzerland
Subject
Life Sciences; Biochemistry, general; Organic Chemistry; Polymer Sciences; Pharmacy
ISSN
1381-1991
eISSN
1573-501X
D.O.I.
10.1007/s11030-017-9742-y
Publisher site
See Article on Publisher Site

Abstract

Deuterium-enriched and fluorine-substituted compounds have been widely applied in drug discovery due to their advantages in the studies of clinical pharmacokinetics and metabolic profiles. Herein we synthesized a library of deuterated and fluorine-substituted plinabulin derivatives, and all 15 D- or F-compounds were characterized by MS, $$^{1}\hbox {H}$$ 1 H NMR and $$^{ 13}\hbox {C}\,\hbox {NMR}$$ 13 C NMR . Their antitumor activities were evaluated against human Jurkat T lymphocyte cells.

Journal

Molecular DiversitySpringer Journals

Published: May 9, 2017

References

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