Synthesis of a polyamidoamine dendron-bearing lipid having sugar moieties and its use for preparation of nonviral gene vectors

Synthesis of a polyamidoamine dendron-bearing lipid having sugar moieties and its use for... We have so far developed a new type of cationic lipid that consists of an amine-terminated poly(amidoamine) dendron and two long alkyl chains. In this study, we designed a dendron-bearing lipid (DL) modified with sugar moieties as the ligand at the terminal groups of the dendron to improve the transfection activities. We combined lactobionic acid at the end of every dendritic branch of the DL to produce galactose moieties-attached DL (Gal-DL). The lipoplexes containing Gal-DL exhibited enhancement of transfection of HepG2 cells. Moreover, Gal-DL significantly promoted the transfection activity of the lipoplexes including poly(ethylene glycol)-attached dendron-bearing lipid (PEG-DL). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis of a polyamidoamine dendron-bearing lipid having sugar moieties and its use for preparation of nonviral gene vectors

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Publisher
Springer Journals
Copyright
Copyright © 2009 by Springer Science+Business Media BV
Subject
Chemistry; Inorganic Chemistry ; Physical Chemistry ; Catalysis
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-009-0083-z
Publisher site
See Article on Publisher Site

Abstract

We have so far developed a new type of cationic lipid that consists of an amine-terminated poly(amidoamine) dendron and two long alkyl chains. In this study, we designed a dendron-bearing lipid (DL) modified with sugar moieties as the ligand at the terminal groups of the dendron to improve the transfection activities. We combined lactobionic acid at the end of every dendritic branch of the DL to produce galactose moieties-attached DL (Gal-DL). The lipoplexes containing Gal-DL exhibited enhancement of transfection of HepG2 cells. Moreover, Gal-DL significantly promoted the transfection activity of the lipoplexes including poly(ethylene glycol)-attached dendron-bearing lipid (PEG-DL).

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Oct 14, 2009

References

  • Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications
    Lima, MCP; Simoes, S; Pires, P; Faneca, H; Duzgunes, N
  • Fusion of cationic liposomes with mammalian cells occurs after endocytosis
    Wrobel, I; Collins, D
  • The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer
    Farhood, H; Serbina, N; Huang, L
  • In vivo gene delivery to the liver using novel galactosylated cationic liposomes
    Kawakami, S; Fumoto, S; Nishikawa, M; Yamashita, F; Hashida, M
  • Lipid fusion in oligonucleotide and gene delivery with cationic lipids
    Monkkonen, J; Urtti, A

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