Synthesis of 5-phenyl-3-(10H-phenothiazinyl)-Δ2-cyclohexen-1-ones by conventional and microwave-assisted methods and their antifungal activity

Synthesis of 5-phenyl-3-(10H-phenothiazinyl)-Δ2-cyclohexen-1-ones by conventional and... A series of 5-phenyl-3-(10H-phenothiazinyl)-Δ2-cyclohexen-1-ones were prepared using conventional and microwave-assisted methods. The condensation between 3-phenyl-1-(10H-phenothiazinyl) prop-2-en-1-one derivatives (3a–g) and acetyl acetone yielded 5-phenyl-3-(10H-phenothiazinyl)-Δ2-cyclohexen-1-one derivatives (7a–g). The products were characterized by UV, IR, 1H NMR, 13C NMR, 2D-NMR, MS, and elemental analysis. In vitro antifungal activity was carried out by zone of inhibition method against four species, namely Aspergillus niger, Candida albicans, Microsporum gypseum, and Aspergillus flavus. Compounds 7a and 7d showed good antifungal activity with zones of inhibition of 17 and 18 mm, respectively, and comparable with the standard substance, Bavinston, with 20 mm. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis of 5-phenyl-3-(10H-phenothiazinyl)-Δ2-cyclohexen-1-ones by conventional and microwave-assisted methods and their antifungal activity

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Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1153-9
Publisher site
See Article on Publisher Site

Abstract

A series of 5-phenyl-3-(10H-phenothiazinyl)-Δ2-cyclohexen-1-ones were prepared using conventional and microwave-assisted methods. The condensation between 3-phenyl-1-(10H-phenothiazinyl) prop-2-en-1-one derivatives (3a–g) and acetyl acetone yielded 5-phenyl-3-(10H-phenothiazinyl)-Δ2-cyclohexen-1-one derivatives (7a–g). The products were characterized by UV, IR, 1H NMR, 13C NMR, 2D-NMR, MS, and elemental analysis. In vitro antifungal activity was carried out by zone of inhibition method against four species, namely Aspergillus niger, Candida albicans, Microsporum gypseum, and Aspergillus flavus. Compounds 7a and 7d showed good antifungal activity with zones of inhibition of 17 and 18 mm, respectively, and comparable with the standard substance, Bavinston, with 20 mm.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Mar 21, 2013

References

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