Synthesis of (3-(naphthalen-1-yl)oxiran-2-yl)(5,6,7,8-tetrahydronaphthalen-2-yl)methanone and reaction with some nucleophiles for anticancer evaluation

Synthesis of (3-(naphthalen-1-yl)oxiran-2-yl)(5,6,7,8-tetrahydronaphthalen-2-yl)methanone and... (3-(Naphthalen-1-yl)oxiran-2-yl)(5,6,7,8-tetrahydronaphthalen-2-yl)methanone was prepared and allowed to react with different nucleophile agents such as hydrazine hydrate, phenyl hydrazine, methyl hydrazine, and hydroxylamine hydrochloride to give hydroxy pyrazole 2 and hydroxy oxazole 3. Also, oxirane 1 reacted with semicarbazide and thiosemicarbazide to give substituted pyrazole 4a,b. Also, oxirane 1 was allowed to react with carbon disulfide, glycine, substituted isothiocyanate, and thiourea to give compounds 5–8, respectively. The thiopyrimidine derivative 8 was cyclized by chloroacetic acid or ethyl bromoacetate to give thiazolidine derivative 9, which condensed with different aldehydes to give compound 10a–c. Some of these newly synthesized compounds were evaluated as anticancer agents. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis of (3-(naphthalen-1-yl)oxiran-2-yl)(5,6,7,8-tetrahydronaphthalen-2-yl)methanone and reaction with some nucleophiles for anticancer evaluation

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Publisher
Springer Netherlands
Copyright
Copyright © 2014 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-014-1679-5
Publisher site
See Article on Publisher Site

Abstract

(3-(Naphthalen-1-yl)oxiran-2-yl)(5,6,7,8-tetrahydronaphthalen-2-yl)methanone was prepared and allowed to react with different nucleophile agents such as hydrazine hydrate, phenyl hydrazine, methyl hydrazine, and hydroxylamine hydrochloride to give hydroxy pyrazole 2 and hydroxy oxazole 3. Also, oxirane 1 reacted with semicarbazide and thiosemicarbazide to give substituted pyrazole 4a,b. Also, oxirane 1 was allowed to react with carbon disulfide, glycine, substituted isothiocyanate, and thiourea to give compounds 5–8, respectively. The thiopyrimidine derivative 8 was cyclized by chloroacetic acid or ethyl bromoacetate to give thiazolidine derivative 9, which condensed with different aldehydes to give compound 10a–c. Some of these newly synthesized compounds were evaluated as anticancer agents.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jun 10, 2014

References

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