A series of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-ones have been synthesized in good yields by reaction of 4-amino-2-methylpyrimidine-5-carboxamide with aromatic aldehydes in the presence of three heteropolyacids, H3PMo12O40, H3PW12O40, and H5PV2Mo10O40. In this reaction the catalytic activity of H3PMo12O40 and H3PW12O40 was lower than that of H5PV2Mo10O40. All the synthesized compounds were characterized on the basis of elemental analysis and spectral data (IR, 1H NMR, 13C NMR, and ESIMS). It is an effective way of synthesis of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-one derivatives, with the advantages of mild reaction conditions, simple operation, and good yields.
Research on Chemical Intermediates – Springer Journals
Published: May 24, 2013
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud