Synthesis of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-ones catalyzed by heteropolyacids

Synthesis of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-ones catalyzed by heteropolyacids A series of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-ones have been synthesized in good yields by reaction of 4-amino-2-methylpyrimidine-5-carboxamide with aromatic aldehydes in the presence of three heteropolyacids, H3PMo12O40, H3PW12O40, and H5PV2Mo10O40. In this reaction the catalytic activity of H3PMo12O40 and H3PW12O40 was lower than that of H5PV2Mo10O40. All the synthesized compounds were characterized on the basis of elemental analysis and spectral data (IR, 1H NMR, 13C NMR, and ESIMS). It is an effective way of synthesis of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-one derivatives, with the advantages of mild reaction conditions, simple operation, and good yields. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-ones catalyzed by heteropolyacids

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Publisher
Springer Netherlands
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1266-1
Publisher site
See Article on Publisher Site

Abstract

A series of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-ones have been synthesized in good yields by reaction of 4-amino-2-methylpyrimidine-5-carboxamide with aromatic aldehydes in the presence of three heteropolyacids, H3PMo12O40, H3PW12O40, and H5PV2Mo10O40. In this reaction the catalytic activity of H3PMo12O40 and H3PW12O40 was lower than that of H5PV2Mo10O40. All the synthesized compounds were characterized on the basis of elemental analysis and spectral data (IR, 1H NMR, 13C NMR, and ESIMS). It is an effective way of synthesis of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-one derivatives, with the advantages of mild reaction conditions, simple operation, and good yields.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: May 24, 2013

References

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