1,2,9-Trisubstituted purin-6(9H)-ones have been synthesized in high yield by reaction of 5-amino-N,1-dimethyl-1H-imidazole-4-carboxamide with aromatic aldehydes in the presence of heteropolyacids, H3PMo12O40 and H5PV2Mo10O40. The catalytic activity of H3PMo12O40 is lower than that of H5PV2Mo10O40. This is an effective synthesis of l,2,9-trisubstituted guanine derivatives with the advantages of mild reaction conditions, simple operation, and good yields.
Research on Chemical Intermediates – Springer Journals
Published: Dec 25, 2012
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