Synthesis of 1,2,9-trisubstituted purin-6(9H)-ones catalyzed by heteropolyacids

Synthesis of 1,2,9-trisubstituted purin-6(9H)-ones catalyzed by heteropolyacids 1,2,9-Trisubstituted purin-6(9H)-ones have been synthesized in high yield by reaction of 5-amino-N,1-dimethyl-1H-imidazole-4-carboxamide with aromatic aldehydes in the presence of heteropolyacids, H3PMo12O40 and H5PV2Mo10O40. The catalytic activity of H3PMo12O40 is lower than that of H5PV2Mo10O40. This is an effective synthesis of l,2,9-trisubstituted guanine derivatives with the advantages of mild reaction conditions, simple operation, and good yields. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis of 1,2,9-trisubstituted purin-6(9H)-ones catalyzed by heteropolyacids

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Publisher
Springer Netherlands
Copyright
Copyright © 2012 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-012-0936-8
Publisher site
See Article on Publisher Site

Abstract

1,2,9-Trisubstituted purin-6(9H)-ones have been synthesized in high yield by reaction of 5-amino-N,1-dimethyl-1H-imidazole-4-carboxamide with aromatic aldehydes in the presence of heteropolyacids, H3PMo12O40 and H5PV2Mo10O40. The catalytic activity of H3PMo12O40 is lower than that of H5PV2Mo10O40. This is an effective synthesis of l,2,9-trisubstituted guanine derivatives with the advantages of mild reaction conditions, simple operation, and good yields.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Dec 25, 2012

References

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