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O. Dolomanov, L. Bourhis, R. Gildea, J. Howard, H. Puschmann (2009)
OLEX2: a complete structure solution, refinement and analysis programJournal of Applied Crystallography, 42
M. González-Álvarez, G. Alzuet, J. Borrás, B. Macías, A. Castiñeiras (2003)
Oxidative cleavage of DNA by a new ferromagnetic linear trinuclear copper(II) complex in the presence of H2O2/sodium ascorbate.Inorganic chemistry, 42 9
J. Pedregosa, G. Alzuet, J. Borrás, S. Fustero, S. García‐Granda, M. Díaz (1993)
Structure of 5-amino-1,3,4-thiadiazole-2-sulfonamide, an inhibitor of the enzyme carbonic anhydraseActa Crystallographica Section C-crystal Structure Communications, 49
M. González-Álvarez, G. Alzuet, J. Borrás, L. Agudo, S. García‐Granda, Jose Bernardo (2004)
Strong protective action of Copper(II) N-substituted sulfonamide complexes against reactive oxygen species.Journal of inorganic biochemistry, 98 2
S. Ferrer, J. Haasnoot, R. Graaff, J. Reedijk, J. Borrás (1992)
Synthesis, crystal structure and properties of two acetazolamide (5-acetamido-1,3,4-thiadiazole-2-sulfonamide) complexes: bis(5-acetamidato- 1,3,4-thiadiazole-2-sulfonamide-O)bis( 1,2-ethanediamine)copper(II) and bis(5-acetamidato-1,3,4-thiadiazole-2-sulfonamide-N)bis(1,3- propanediamine)copper(II);Inorganica Chimica Acta, 192
F. Pamatong, C. Detmer, J. Bocarsly (1996)
Double-Strand Cleavage of DNA by a Monofunctional Transition Metal Cleavage AgentJournal of the American Chemical Society, 118
M. González-Álvarez, G. Alzuet, J. Borrás, B. Macías, M. Olmo, M. Liu-González, F. Sanz (2002)
Nuclease activity of [Cu(sulfathiazolato)(2)(benzimidazole)(2)]2MeOH. Synthesis, properties and crystal structure.Journal of inorganic biochemistry, 89 1-2
Carl Otter, S. Couchman, J. Jeffery, K. Mann, E. Psillakis, M. Ward (1998)
Complexes of a new bidentate chelating pyridyl/sulfonamide ligand with copper(II), cobalt(II) and palladium(II): crystal structures and spectroscopic propertiesInorganica Chimica Acta, 278
M. Graf, B. Greaves, H. Stoeckli-Evans (1993)
Crystal and molecular structures of Cu(II) and Zn(II) complexes of 2,3,5,6-tetra(2-pyridyl)pyrazine (TPPZ) : an old ligand revisitedInorganica Chimica Acta, 204
B. Macías, M. Villa, B. Gómez, J. Borrás, G. Alzuet, M. González-Álvarez, A. Castiñeiras (2007)
DNA interaction of new copper(II) complexes with sulfonamides as ligands.Journal of inorganic biochemistry, 101 3
Elisa Borrás, G. Alzuet, J. Borrás, J. Server-Carrió, A. Castiñeiras, M. Liu-González, F. Sanz-Ruiz (2000)
Coordination chemistry of sulfamethizole: crystal structures of [Cu(sulfamethizolate)2(py)2(OH2)]·H2O, [M(sulfamethizolate)2(py)2(OH2)2] [M=Co and Ni] and {Cu(sulfamethizolate)2(dmf)2}∞Polyhedron, 19
Carolyn Brock (2019)
International Tables for CrystallographyInternational Tables for Crystallography
Changlin Liu, Jinyan Zhou, Qingxiang Li, Lijun Wang, Zenru Liao, Hui-Bie Xu (1999)
DNA damage by copper(II) complexes: coordination-structural dependence of reactivities.Journal of inorganic biochemistry, 75 3
K. Wong, S. Colson (1984)
The FT-IR spectra of pyridine and pyridine-d5Journal of Molecular Spectroscopy, 104
R. Cejudo, G. Alzuet, M. González-Álvarez, J. García-Giménez, J. Borrás, M. Liu-González (2006)
DNA cleavage reaction induced by dimeric copper(II) complexes of N-substituted thiazole sulfonamides.Journal of inorganic biochemistry, 100 1
I. Bertini, R. Drago (1979)
ESR and NMR of Paramagnetic Species in Biological and Related Systems : Proceedings of the NATO Advanced Study Institute held at Acquafredda di Maratea, Italy, June 3-15,1979
M. González-Álvarez, G. Alzuet, L. Castillo, J. Borrás, M. Liu-González (2006)
Genotoxic Potential of N-(Benzothiazolyl)sulfonamide Copper(II) Complexes on Yeast Cells Transformed with YEGFP Expression Constructs Containing the RAD54 or RNR2 PromoterEuropean Journal of Inorganic Chemistry, 2006
K. Humphreys, K. Karlin, S. Rokita (2002)
Targeted strand scission of DNA substrates by a tricopper(II) coordination complex.Journal of the American Chemical Society, 124 27
Angela Theodorou, M. Demertzis, D. Kovala‐Demertzi, Efthimia Lioliou, A. Pantazaki, D. Kyriakidis (1999)
Copper(II) complexes of diclofenac: Spectroscopic studies and DNA strand breakageBiometals, 12
T. Owa, Hiroshi Yoshino, Tatsuo Okauchi, K. Yoshimatsu, Yoichi Ozawa, N. Sugi, T. Nagasu, N. Koyanagi, K. Kitoh (1999)
Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle.Journal of medicinal chemistry, 42 19
B. Macías, Isabel Garcı́a, M. Villa, J. Borrás, M. González-Álvarez, A. Castiñeiras (2003)
Structural characterisation and nuclease activity of mixed copper(II) complexes with sulfonamides and bipyridilInorganica Chimica Acta, 353
M. González-Álvarez, G. Alzuet, J. Borrás, M. Pitié, B. Meunier (2003)
DNA cleavage studies of mononuclear and dinuclear copper(II) complexes with benzothiazolesulfonamide ligandsJBIC Journal of Biological Inorganic Chemistry, 8
J. García-Giménez, G. Alzuet, M. González-Álvarez, A. Castiñeiras, M. Liu-González, J. Borrás (2007)
A dinuclear copper(II) complex with adeninate bridge ligands and prominent DNA cleavage activity. Structural and spectroscopic characterization and magnetic properties.Inorganic chemistry, 46 17
J. García-Giménez, G. Alzuet, M. González-Álvarez, M. Liu-González, A. Castiñeiras, J. Borrás (2009)
Oxidative nuclease activity of ferromagnetically coupled mu-hydroxo-mu-propionato copper(II) complexes [Cu3(L)2(mu-OH)2(mu-propionato)2] (L=N-(pyrid-2-ylmethyl)R-sulfonamidato, R=benzene, toluene, naphthalene).Journal of inorganic biochemistry, 103 2
Lei Li, K. Karlin, S. Rokita (2005)
Changing selectivity of DNA oxidation from deoxyribose to Guanine by ligand design and a new binuclear copper complex.Journal of the American Chemical Society, 127 2
A. Thomas, M. Nethaji, A. Chakravarty (2004)
Different modes of DNA cleavage activity of dihydroxo-bridged dicopper(II) complexes having phenanthroline bases.Journal of inorganic biochemistry, 98 6
G. Alzuet, S. Ferrer, J. Borrás, X. Solans, M. Fontbardia (1993)
Coordination behaviour of methazolamide [N(-4-methyl-2-sulfamoyl-Δ2-1,3,4-thiadiazolin-5-ylidene)] acetamide, an inhibitor of carbonic anhydrase enzyme. Synthesis, crystal structure and properties of bis(methazolamidate)tetrammine nickel(II)Inorganica Chimica Acta, 203
M. González-Álvarez, G. Alzuet, J. Borrás, Lucas Castillo-Agudo, J. Montejo-Bernardo, Ángel Gutiérrez-Rodríguez, S. García‐Granda (2008)
Evaluation of antiproliferative activities and apoptosis induction caused by copper(II)–benzothiazolesulfonamide complexes in Jurkat T lymphocytes and Caco-2 cellsJBIC Journal of Biological Inorganic Chemistry, 13
C. Detmer, F. Pamatong, J. Bocarsly (1996)
Nonrandom Double Strand Cleavage of DNA by a Monofunctional Metal Complex: Mechanistic StudiesInorganic Chemistry, 35
D. Sigman, M. Kuwabara, C. Chen, T. Bruice (1991)
Nuclease activity of 1,10-phenanthroline-copper in study of protein-DNA interactions.Methods in enzymology, 208
A. Hangan, J. Borrás, M. Liu-González, L. Oprean (2007)
Synthesis, Crystal Structures and Properties of [Cu(L1)2(py)2(H2O)](H2O) [HL1 = N-(5-ethyl-[1,3,4]–thiadiazole-2-yl)-toluenesulfonamidate] and [Cu(L2)2(py)2(H2O)] [HL2 = N-(5-ethyl-[1,3,4]–thiadiazole-2-yl)-benzenesulfonamidate]†Zeitschrift für anorganische und allgemeine Chemie, 633
G. Alzuet, S. Ferrer, J. Borrás, X. Solans (1991)
Structure of methazolamide: an inhibitor of carbonic anhydraseActa Crystallographica Section C-crystal Structure Communications, 47
B. Macías, Isabel Garcı́a, M. Villa, J. Borrás, M. González-Álvarez, A. Castiñeiras (2003)
Oxidative DNA damage of mixed copper(II) complexes with sulfonamides and 1,10-phenanthroline. Crystal structure of [Cu(N-quinolin-8-yl-p-toluenesulfonamidate)2(1,10-phenanthroline)].Journal of inorganic biochemistry, 96 2-3
A new N-sulfonamide ligand, N-(5-(4-methylphenyl)-[1,3,4]-thiadiazole-2-yl)toluenesulfonamide (HL) and its Cu(II) complex [Cu(L)2(Py)2(H2O)] (I), have been synthesized. The X-ray crystal structure of the ligand and of complex I have been determined (CIF files CCDC nos. 975153 (HL), 851790 (I)). In I, the Cu2+ ion is five-coordinated, forming a CuN4O chromophore. The ligand acts as monodentate, coordinating the metal ion through a single Nthiadiazole atom. The molecules from the reaction medium (pyridine and water) are also involved in the coordination of the Cu2+ ion. Complex I has a slightly distorted square pyramidal geometry. The complex was characterized by FT-IR, electronic, EPR spectroscopic and magnetic methods. The nuclease activity studies of the synthesized complex confirm his capacity to cleavage the DNA molecule. The ligand has two important roles in the nuclease activity of I: it influence the reactivity of the Cu2+ ion and interact with DNA molecule. The complex interacts with the DNA molecule. Immediately, the Cu2+ ion is reduced to Cu(I), and in the presence of molecular oxygen the formed Cu(I) complex produces reactive oxygen species in close proximity to the double helix.
Russian Journal of Coordination Chemistry – Springer Journals
Published: Jun 3, 2015
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