Synthesis, crystal structure, properties, and nuclease activity of a new Cu(II) complex [Cu(L)2(Py)2(H2O)] (HL = N-(5-(4-methylphenyl)-[1,3,4]-thiadiazole-2-yl)toluenesulfonamide)

Synthesis, crystal structure, properties, and nuclease activity of a new Cu(II) complex... A new N-sulfonamide ligand, N-(5-(4-methylphenyl)-[1,3,4]-thiadiazole-2-yl)toluenesulfonamide (HL) and its Cu(II) complex [Cu(L)2(Py)2(H2O)] (I), have been synthesized. The X-ray crystal structure of the ligand and of complex I have been determined (CIF files CCDC nos. 975153 (HL), 851790 (I)). In I, the Cu2+ ion is five-coordinated, forming a CuN4O chromophore. The ligand acts as monodentate, coordinating the metal ion through a single Nthiadiazole atom. The molecules from the reaction medium (pyridine and water) are also involved in the coordination of the Cu2+ ion. Complex I has a slightly distorted square pyramidal geometry. The complex was characterized by FT-IR, electronic, EPR spectroscopic and magnetic methods. The nuclease activity studies of the synthesized complex confirm his capacity to cleavage the DNA molecule. The ligand has two important roles in the nuclease activity of I: it influence the reactivity of the Cu2+ ion and interact with DNA molecule. The complex interacts with the DNA molecule. Immediately, the Cu2+ ion is reduced to Cu(I), and in the presence of molecular oxygen the formed Cu(I) complex produces reactive oxygen species in close proximity to the double helix. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Coordination Chemistry Springer Journals

Synthesis, crystal structure, properties, and nuclease activity of a new Cu(II) complex [Cu(L)2(Py)2(H2O)] (HL = N-(5-(4-methylphenyl)-[1,3,4]-thiadiazole-2-yl)toluenesulfonamide)

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Publisher
Pleiades Publishing
Copyright
Copyright © 2015 by Pleiades Publishing, Ltd.
Subject
Chemistry; Physical Chemistry; Inorganic Chemistry
ISSN
1070-3284
eISSN
1608-3318
D.O.I.
10.1134/S1070328415050024
Publisher site
See Article on Publisher Site

Abstract

A new N-sulfonamide ligand, N-(5-(4-methylphenyl)-[1,3,4]-thiadiazole-2-yl)toluenesulfonamide (HL) and its Cu(II) complex [Cu(L)2(Py)2(H2O)] (I), have been synthesized. The X-ray crystal structure of the ligand and of complex I have been determined (CIF files CCDC nos. 975153 (HL), 851790 (I)). In I, the Cu2+ ion is five-coordinated, forming a CuN4O chromophore. The ligand acts as monodentate, coordinating the metal ion through a single Nthiadiazole atom. The molecules from the reaction medium (pyridine and water) are also involved in the coordination of the Cu2+ ion. Complex I has a slightly distorted square pyramidal geometry. The complex was characterized by FT-IR, electronic, EPR spectroscopic and magnetic methods. The nuclease activity studies of the synthesized complex confirm his capacity to cleavage the DNA molecule. The ligand has two important roles in the nuclease activity of I: it influence the reactivity of the Cu2+ ion and interact with DNA molecule. The complex interacts with the DNA molecule. Immediately, the Cu2+ ion is reduced to Cu(I), and in the presence of molecular oxygen the formed Cu(I) complex produces reactive oxygen species in close proximity to the double helix.

Journal

Russian Journal of Coordination ChemistrySpringer Journals

Published: Jun 3, 2015

References

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