ISSN 10703284, Russian Journal of Coordination Chemistry, 2015, Vol. 41, No. 11, pp. 772–776. © Pleiades Publishing, Ltd., 2015.
Schiff bases represent one of the most widely uti
lized classes of ligands in metal coordination chemis
try. They offer versatile and flexible ligands capable of
binding various metal ions to give complexes with ver
satile structures and properties [1–5]. Over the past
few decades considerable study has been made on the
chemistry of manganese(III) complexes derived from
Schiff base ligands due to their important role in cata
lytic, magnetic and biological properties [6–10]. In
addition, manganese plays an important role in metal
loenzymes such as catalase , superoxide dismutase
[12, 13], and photosystem II of green plants [14, 15].
An important aspect of Mn(III) salen type complexes
is their antibacterial application [16–18]. We report
here the synthesis, characterization including single
crystal Xray structure of a new manganese(III) com
), where L is
the dianionic form of
L). The antibacterial
activity against three Grampositive bacterial strains
) and three
Gramnegative bacterial strains (
) by MTT method was studied.
Materials and physical methods.
The Schiff base
L was prepared by 2 : 1 condensation of
The article is published in the original.
5methylsalicylaldehyde and 4chloro
diamine in methanol, according to the literature
method . All the other reagents and solvents were
purchased from commercial sources and used as re
ceived. FTIR spectra were recorded as KBr pellets on
Bruker Tensor27. Elemental (C, H, and N) analyses
were performed on a PerkinElmer 2400 II analyzer.
Single crystal Xray diffraction was carried out with a
Bruker Apex II CCD diffratometer. Magnetic suscep
tibility measurement was carried out with a Sherwood
Scientific Co., UK magnetic susceptibility balance.
Electronic spectra were obtained with Lambda 900
spectrophotometer. Molar conductivity of the com
plex in acetonitrile was measured with a DDS11A
molar conductivity meter.
! Perchlorate and azide complexes of metal
ions are potentially explosive. Only a small amount of
material should be prepared, and it should be handled
Synthesis of complex I.
To a stirred suspension of
L (0.378 g, 1.00 mmol) and sodium azide (0.130 g,
2.00 mmol) in methanol (20 mL) was added dropwise
a methanol solution (10 mL) of manganese(II) per
chlorate hexahydrate (0.254 g, 1.00 mmol). After a few
minutes a brown precipitate started to deposit. This
was dissolved by adding the requisite amount of aceto
nitrile. After one hour stirring, the solution was filtered
and the filtrate was kept for slow evaporation. The dif
fraction quality deep brown single crystals that depos
ited over a period of a few days were collected by filtra
Synthesis, Crystal Structure, and Antibacterial Activity
of a Manganese(III) Complex Derived from
L. Xue, D. N. Deng, Y. Xu, and Q. Wang*
Modern Medical Research Center, Third Affiliated Hospital of Soochow University, Changzhou, 213003 P.R. China
Received March 17, 2015
A new mononuclear manganese(III) complex has been synthesized from the Schiff base com
3,4chlorophenylenebis(5methylsalicylaldimine) and manganese perchlorate in the presence
of sodium azide. The complex has been characterized by physicochemical and spectroscopic methods, as
well as single crystal Xray determination (CIF file CCDC no. 1054335). The Mn atom in the complex is six
coordinate by two nitrogen and two oxygen atoms of the Schiff base ligand, one nitrogen atom of an azide
ligand, and one oxygen atom of a methanol ligand. Crystal structure of the complex is stabilized by hydrogen
interactions. The complex and the Schiff base compound were assayed for antibacterial activ
ities against three Grampositive bacterial strains (
) and three Gramneg
ative bacterial strains (
) by MTT method. As a result, the complex showed
effective antimicrobial activity against the microorganisms tested.