Synthesis, characterization, antibacterial activity in dark and in vitro cytocompatibility of Ag-incorporated TiO2 microspheres with high specific surface area

Synthesis, characterization, antibacterial activity in dark and in vitro cytocompatibility of... Postoperative infection associated with medical implants is a devastating complication of orthopedic surgery. Considering the difficulties for the diagnosis and treatment of infection, coating the implant material with antibacterial substances is a promising protocol by which to avoid such an adverse reaction. Nanoparticles (NPs) constructed of anatase microspheres, one form of titanium dioxide (TiO2), with a high specific surface area are fabricated in this study in a facile one-step process using homogeneous precipitation at 90 °C under atmospheric pressure using titanium sulfate (Ti[SO4]2) and urea as the titanium source and precipitant, respectively. The molar ratio of silver (Ag) to TiO2 can be changed by varying the amount of silver nitrate (AgNO3). The high specific surface area of the TiO2 microspheres combined with Ag particles (Ag/TiO2) exhibit excellent antibacterial properties against both Staphylococcus aureus and Escherichia coli. In addition, the Ag/TiO2 material in this work possesses satisfactory biological performance on MC3T3-E1 cells. The high specific surface area of Ag/TiO2 together with good antibacterial properties and cytocompatibility provide promising applications in dentistry, orthopedics, and other fields of medicine that use biomedical devices. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Materials Science: Materials in Medicine Springer Journals

Synthesis, characterization, antibacterial activity in dark and in vitro cytocompatibility of Ag-incorporated TiO2 microspheres with high specific surface area

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Materials Science; Biomaterials; Biomedical Engineering; Regenerative Medicine/Tissue Engineering; Polymer Sciences; Ceramics, Glass, Composites, Natural Materials; Surfaces and Interfaces, Thin Films
ISSN
0957-4530
eISSN
1573-4838
D.O.I.
10.1007/s10856-018-6042-8
Publisher site
See Article on Publisher Site

Abstract

Postoperative infection associated with medical implants is a devastating complication of orthopedic surgery. Considering the difficulties for the diagnosis and treatment of infection, coating the implant material with antibacterial substances is a promising protocol by which to avoid such an adverse reaction. Nanoparticles (NPs) constructed of anatase microspheres, one form of titanium dioxide (TiO2), with a high specific surface area are fabricated in this study in a facile one-step process using homogeneous precipitation at 90 °C under atmospheric pressure using titanium sulfate (Ti[SO4]2) and urea as the titanium source and precipitant, respectively. The molar ratio of silver (Ag) to TiO2 can be changed by varying the amount of silver nitrate (AgNO3). The high specific surface area of the TiO2 microspheres combined with Ag particles (Ag/TiO2) exhibit excellent antibacterial properties against both Staphylococcus aureus and Escherichia coli. In addition, the Ag/TiO2 material in this work possesses satisfactory biological performance on MC3T3-E1 cells. The high specific surface area of Ag/TiO2 together with good antibacterial properties and cytocompatibility provide promising applications in dentistry, orthopedics, and other fields of medicine that use biomedical devices.

Journal

Journal of Materials Science: Materials in Medicine – Springer Journals

Published: Apr 23, 2018

References

  • Lack of toxicological side-effects in silver-coated megaprostheses in humans
    Hardes, J; Ahrens, H; Gebert, C; Streitbuerger, A; Buerger, H; Erren, M
  • Etiology of deep sepsis in total hip arthroplasty. The significance of hematogenous and recurrent infections
    Schmalzried, TP; Amstutz, HC; Au, MK; Dorey, FJ
  • The role of biofilms as environmental reservoirs of antibiotic resistance
    Balcazar, JL; Subirats, J; Borrego, CM
  • Effect of vancomycin and rifampicin on meticillin-resistant Staphylococcus aureus biofilms
    Jones, SM; Morgan, M; Humphrey, TJ; Lappin-Scott, H
  • Antibacterial nano-structured titania coating incorporated with silver nanoparticles
    Zhao, L; Wang, H; Huo, K; Cui, L; Zhang, W; Ni, H
  • Towards long lasting zirconia-based composites for dental implants. Part I: innovative synthesis, microstructural characterization and in vitro stability
    Palmero, P; Fornabaio, M; Montanaro, L; Reveron, H; Esnouf, C; Chevalier, J
  • Biomaterials differentially regulate Src kinases and phosphoinositide 3-kinase-gamma in polymorphonuclear leukocyte primary and tertiary granule release
    Cohen, HC; Frost, DC; Lieberthal, TJ; Li, L; Kao, WJ
  • The effects of electrospun substrate-mediated cell colony morphology on the self-renewal of human induced pluripotent stem cells
    Maldonado, M; Wong, LY; Echeverria, C; Ico, G; Low, K; Fujimoto, T
  • Modulation of integrin and E-cadherin-mediated adhesions to spatially control heterogeneity in human pluripotent stem cell differentiation
    Toh, YC; Xing, J; Yu, H
  • “Paintable” 3D printed structures via a post-ATRP process with antimicrobial function for biomedical applications
    Guo, Q; Cai, X; Wang, X; Yang, J
  • Biocompatible slippery fluid-infused films composed of chitosan and alginate via layer-by-layer self-assembly and their antithrombogenicity
    Manabe, K; Kyung, KH; Shiratori, S
  • Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different alpha-helical propensity
    Zhu, X; Zhang, L; Wang, J; Ma, Z; Xu, W; Li, J
  • Preparation and antimicrobial activity of terpene-based polyurethane coatings with carbamate group-containing quaternary ammonium salts
    Liu, G; Wu, G; Jin, C; Kong, Z
  • Drug release and bone growth studies of antimicrobial peptide-loaded calcium phosphate coating on titanium
    Kazemzadeh-Narbat, M; Noordin, S; Masri, BA; Garbuz, DS; Duncan, CP; Hancock, RE
  • Coatings and surface modifications imparting antimicrobial activity to orthopedic implants
    Kargupta, R; Bok, S; Darr, CM; Crist, BD; Gangopadhyay, K; Gangopadhyay, S
  • Titanium oxide antibacterial surfaces in biomedical devices
    Visai, L; Nardo, L; Punta, C; Melone, L; Cigada, A; Imbriani, M
  • A surface science perspective on photocatalysis
    Henderson, MA
  • Capture, store, and discharge. Shuttling photogenerated electrons across TiO2-silver interface
    Takai, A; Kamat, PV
  • Enhanced inactivation of bacteria with silver-modified mesoporous TiO2 under weak ultraviolet irradiation
    Maa, J; Xiong, Z; David Waite, T; Jern, NgcW; Zhao, X
  • Multiple parameters for the comprehensive evaluation of the susceptibility of Escherichia coli to the silver ion
    Zhao, G; Stevens, SE
  • The effects of annealing treatment on microstructure and contact resistance properties of cold sprayed Ag-SnO2 coating
    Wang, J; Wang, C; Kang, YQ
  • Continuing professional development and the Journal of Hospital Infection
    Rathbun, RC; Liedtke, MD
  • An innovative, easily fabricated, silver nanoparticle-based titanium implant coating: development and analytical characterization
    Giglio, E; Cafagna, D; Cometa, S; Allegretta, A; Pedico, A; Giannossa, LC
  • Adsorption of gases in multimolecular layers
    Brunauer, S; Emmett, PH; Teller, E
  • Layer-by-layer structured films of TiO2 nanoparticles and poly(acrylic acid) on electrospun nanofibres
    Ding, B; Kim, J; Kimura, E; Shiratori, S
  • Antibacterial activity and increased bone marrow stem cell functions of Zn-incorporated TiO2 coatings on titanium
    Hu, H; Zhang, W; Qiao, Y; Jiang, X; Liu, X; Ding, C
  • Application of the photocatalytic chemistry of titanium dioxide to disinfection and the killing of cancer cells
    Blake, DM; Maness, PC; Huang, Z; Wolfrum, EJ; Huang, J; Jacoby, WA
  • Raman investigations of TiO2 nanotube substrates covered with thin Ag or Cu deposits
    Roguska, A; Kudelski, A; Pisarek, M; Lewandowska, M; Dolata, M; Janik-Czachor, M
  • Synthesis of Cu-doped TiO2 nanorods with various aspect ratios and dopant concentrations
    You, M; Kim, TG; Sung, TG
  • Enhancement of stability of N-doped TiO2 photocatalysts with Ag loading
    Gao, Y; Fang, P; Chen, F; Liu, Y; Liu, Z; Wang, D
  • Effect of surface species on Cu-TiO2 photocatalytic activity
    Xin, B; Wang, P; Ding, D; Liu, J; Ren, Z; Fu, H
  • Cu-doped TiO2 nanoparticles/graphene composites for efficient visible-light photocatalysis
    Khalid, NR; Ahmed, E; Hong, ZL; Ahmad, M; Zhang, Y; Khalid, S
  • Controlled growth of monodisperse silica spheres in the micron size range
    Stöber, W; Fink, A; Bohn, E
  • Chitosan-PVP-nano silver oxide wound dressing: in vitro and in vivo evaluation
    Archana, D; Singh, BK; Dutta, J; Dutta, PK
  • Electron storage mediated dark antibacterial action of bound silver nanoparticles: smaller is not always better
    Cao, H; Qiao, Y; Liu, X; Lu, T; Cui, T; Meng, F
  • Silver as antibacterial agent: ion, nanoparticle, and metal
    Chernousova, S; Epple, M
  • Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism
    Park, EJ; Yi, J; Kim, Y; Choi, K; Park, K
  • In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells
    Kawata, K; Osawa, M; Okabe, S
  • Surfaces modified with nanometer-thick silver-impregnated polymeric films that kill bacteria but support growth of mammalian cells
    Agarwal, A; Weis, TL; Schurr, MJ; Faith, NG; Czuprynski, CJ; McAnulty, JF

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