Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives

Synthesis, characterization and in vitro antimicrobial activity of novel fused... Background: Some novel substituted pyrazolone, pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4- d]thiazolo[3,2-a]pyrimidinone, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives have been reported to possess various pharmacological activities like antimicrobial, antitumor and anti-inflammatory. Results: A novel series of azoles and azines were designed and prepared via reaction of 1,3-diphenyl-1H-pyrazol- 5(4H)-one with some electrophilic and nucleophilic reagents. The structures of target compounds were confirmed by elemental analyses and spectral data. Conclusions: The antimicrobial activity of the target synthesized compounds were tested against various microor- ganisms such as Escherichia coli; Bacillus megaterium; Bacillus subtilis (Bacterial species), Fusarium proliferatum; Tricho- derma harzianum; Aspergillus niger (fungal species) by the disc diffusion method. In general, the novel synthesized compounds showed a good antimicrobial activity against the previously mentioned microorganisms. Keywords: Substituted pyrazolone, Pyrimidine derivatives, Antimicrobial activity protection [3]. Heterocycles containing a pyrazole or Background pyrazolone nucleus have been reported to show abroad The compounds containing nitrogen are important spectrum of biological activity including antimicrobial category of heterocyclic compounds, which play a sig- [4], anti-cyclooxygenase [5], anti-convulsant [6], antitu- nificant roles in modern pesticide industry (85% of pesti - bercular [7], antitumor [8], anti-inflammatory [ 9], anal- cides with high activity and low toxicity contain nitrogen gesic [10], antidiabetic [11], antipshycotic [12–14]. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry Central Journal Springer Journals

Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives

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Publisher
Springer Journals
Copyright
Copyright © 2017 by The Author(s)
Subject
Chemistry; Chemistry/Food Science, general
eISSN
1752-153X
D.O.I.
10.1186/s13065-017-0339-4
Publisher site
See Article on Publisher Site

Abstract

Background: Some novel substituted pyrazolone, pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4- d]thiazolo[3,2-a]pyrimidinone, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives have been reported to possess various pharmacological activities like antimicrobial, antitumor and anti-inflammatory. Results: A novel series of azoles and azines were designed and prepared via reaction of 1,3-diphenyl-1H-pyrazol- 5(4H)-one with some electrophilic and nucleophilic reagents. The structures of target compounds were confirmed by elemental analyses and spectral data. Conclusions: The antimicrobial activity of the target synthesized compounds were tested against various microor- ganisms such as Escherichia coli; Bacillus megaterium; Bacillus subtilis (Bacterial species), Fusarium proliferatum; Tricho- derma harzianum; Aspergillus niger (fungal species) by the disc diffusion method. In general, the novel synthesized compounds showed a good antimicrobial activity against the previously mentioned microorganisms. Keywords: Substituted pyrazolone, Pyrimidine derivatives, Antimicrobial activity protection [3]. Heterocycles containing a pyrazole or Background pyrazolone nucleus have been reported to show abroad The compounds containing nitrogen are important spectrum of biological activity including antimicrobial category of heterocyclic compounds, which play a sig- [4], anti-cyclooxygenase [5], anti-convulsant [6], antitu- nificant roles in modern pesticide industry (85% of pesti - bercular [7], antitumor [8], anti-inflammatory [ 9], anal- cides with high activity and low toxicity contain nitrogen gesic [10], antidiabetic [11], antipshycotic [12–14].

Journal

Chemistry Central JournalSpringer Journals

Published: Nov 2, 2017

References

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