Background: Some novel substituted pyrazolone, pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4- d]thiazolo[3,2-a]pyrimidinone, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives have been reported to possess various pharmacological activities like antimicrobial, antitumor and anti-inflammatory. Results: A novel series of azoles and azines were designed and prepared via reaction of 1,3-diphenyl-1H-pyrazol- 5(4H)-one with some electrophilic and nucleophilic reagents. The structures of target compounds were confirmed by elemental analyses and spectral data. Conclusions: The antimicrobial activity of the target synthesized compounds were tested against various microor- ganisms such as Escherichia coli; Bacillus megaterium; Bacillus subtilis (Bacterial species), Fusarium proliferatum; Tricho- derma harzianum; Aspergillus niger (fungal species) by the disc diffusion method. In general, the novel synthesized compounds showed a good antimicrobial activity against the previously mentioned microorganisms. Keywords: Substituted pyrazolone, Pyrimidine derivatives, Antimicrobial activity protection . Heterocycles containing a pyrazole or Background pyrazolone nucleus have been reported to show abroad The compounds containing nitrogen are important spectrum of biological activity including antimicrobial category of heterocyclic compounds, which play a sig- , anti-cyclooxygenase , anti-convulsant , antitu- nificant roles in modern pesticide industry (85% of pesti - bercular , antitumor , anti-inflammatory [ 9], anal- cides with high activity and low toxicity contain nitrogen gesic , antidiabetic , antipshycotic [12–14].
Chemistry Central Journal – Springer Journals
Published: Nov 2, 2017
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