Synthesis, characterization, and catalytic application
of PbS nanoparticles for the synthesis of amidoalkyl
naphthols under solvent-free conditions
Ashok V. Borhade
Bhagwat K. Uphade
Dipak R. Tope
Received: 26 September 2012 / Accepted: 24 November 2012 / Published online: 11 December 2012
Ó Springer Science+Business Media Dordrecht 2012
Abstract A simple one-pot synthesis has been developed for the synthesis of
amidoalkyl naphthols using an efﬁcient and recyclable nanocrystalline PbS catalyst
under solvent-free condition. Using this nanocrystalline solid catalyst, the reactions
could be carried out under mild reaction conditions with very good yield (85–95 %).
This catalyst could be recycled very easily, which makes this methodology envi-
ronmentally benign. The biologically active drug-like molecule 1-aminomethyl-2-
naphthol derivatives can be easily obtained from 1-amidomethyl-2-naphthol by
amide hydrolysis reaction in the presence of PbS nanoparticles. Characterization of
the catalyst was performed by X-ray diffraction, transmission electron microscopy,
and adsorption/desorption analysis (BET).
Keywords Lead sulﬁde nanoparticles Á Amidoalkyl naphthols Á
Multicomponent reaction Á Recyclable catalyst
The multicomponent coupling reactions are emerging as useful sources for
accessing small drug-like molecules with several levels of structural diversity.
The multicomponent reaction has attracted the great attention of research groups
working in medicinal chemistry, drug discovery, and material science. In organic
synthesis, heterogeneous catalysts have much more importance due to economic and
environmental considerations . Multicomponent reactions are used to produce the
target products in a single operation which reduce reaction times and energy .
The solvent-free reactions have attracted attention due to environmental problems
A. V. Borhade (&) Á B. K. Uphade Á D. R. Tope
Research Centre, Department of Chemistry, HPT Arts and RYK Science College,
Nasik 422005, India
Res Chem Intermed (2014) 40:211–223