Synthesis, characterization, and biological evaluation of new N-glycosides derived from O-pivaloylated β-d-glucopyranosylamine

Synthesis, characterization, and biological evaluation of new N-glycosides derived from... The novel synthesis of N-(2,3,4,6-tetra-O-pivaloyl-β-d-glucopyranosyl) benzo[d] oxazol-2-amine 4 was described in this study. The new compounds N-arylthioureas 3a-c and 4, along with a series of glucose-modified imines 5a-g, were evaluated for their antitumor activity against human myeloid leukemia cell lines (HL-60 cells), gastric carcinoma (BGC-823 cells), liver carcinoma (Bel-7402 cells), and oral carcinomas (KB cells). The antibacterial potency of these compounds was also determined using an inhibition zone diameter test. Although none of the compounds were active against human cancer cells, compound 4 was found to be the most active compound against Escherichia coli. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis, characterization, and biological evaluation of new N-glycosides derived from O-pivaloylated β-d-glucopyranosylamine

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Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer Science+Business Media B.V.
Subject
Chemistry; Catalysis; Inorganic Chemistry; Physical Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-011-0423-7
Publisher site
See Article on Publisher Site

Abstract

The novel synthesis of N-(2,3,4,6-tetra-O-pivaloyl-β-d-glucopyranosyl) benzo[d] oxazol-2-amine 4 was described in this study. The new compounds N-arylthioureas 3a-c and 4, along with a series of glucose-modified imines 5a-g, were evaluated for their antitumor activity against human myeloid leukemia cell lines (HL-60 cells), gastric carcinoma (BGC-823 cells), liver carcinoma (Bel-7402 cells), and oral carcinomas (KB cells). The antibacterial potency of these compounds was also determined using an inhibition zone diameter test. Although none of the compounds were active against human cancer cells, compound 4 was found to be the most active compound against Escherichia coli.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Oct 30, 2011

References

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