Synthesis, Characterization and Biocompatibility of N-palmitoyl L-alanine-based Organogels as Sustained Implants of Granisetron and Evaluation of thier Antiemetic Effect

Synthesis, Characterization and Biocompatibility of N-palmitoyl L-alanine-based Organogels as... Pharm Res (2018) 35:149 https://doi.org/10.1007/s11095-018-2433-2 RESEARCH PAPER Synthesis, Characterization and Biocompatibility of N-palmitoyl L-alanine-based Organogels as Sustained Implants of Granisetron and Evaluation of thier Antiemetic Effect 1 2 3 3 Hala Bakr El-Nassan & Aliaa Nabil ElMeshad & Walaa Wadie & Rabab H. Sayed Received: 18 March 2018 /Accepted: 18 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 . . . KEY WORDS antiemesis cisplatin granisetron ABSTRACT Purpose To assess the gelation power of N-palmitoyl L- N-palmitoyl L-alanine organogel alanine derivatives in injectable oils and to use the best chosen organogel as parenteral implant of granisetron for the treat- ment of emesis. ABBREVIATIONS Methods Twelve N-palmitoyl L-alanine derived organogels CGC Critical gelling concentration were developed and evaluated in terms of morphology, ther- DSC Differential scanning calorimetry mal properties and in vivo performance. The ability of the se- GRAS Generally Regarded As Safe lected formula to form in situ gel upon subcutaneous injection H-bond Hydrogen bond in rats and its biocompatibility were monitored over 2 weeks by LA N-lauroyl L-alanine histopathological examination of the injection site. LAM N-lauroyl L-alanine methyl ester Results Theacidderivative(N-palmitoyl L-alanine; PA)was LMWOGs Low molecular weight organogelators superior to ester derivatives. The chosen http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Research Springer Journals

Synthesis, Characterization and Biocompatibility of N-palmitoyl L-alanine-based Organogels as Sustained Implants of Granisetron and Evaluation of thier Antiemetic Effect

Loading next page...
 
/lp/springer_journal/synthesis-characterization-and-biocompatibility-of-n-palmitoyl-l-4SB7Y78hHI
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering
ISSN
0724-8741
eISSN
1573-904X
D.O.I.
10.1007/s11095-018-2433-2
Publisher site
See Article on Publisher Site

Abstract

Pharm Res (2018) 35:149 https://doi.org/10.1007/s11095-018-2433-2 RESEARCH PAPER Synthesis, Characterization and Biocompatibility of N-palmitoyl L-alanine-based Organogels as Sustained Implants of Granisetron and Evaluation of thier Antiemetic Effect 1 2 3 3 Hala Bakr El-Nassan & Aliaa Nabil ElMeshad & Walaa Wadie & Rabab H. Sayed Received: 18 March 2018 /Accepted: 18 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 . . . KEY WORDS antiemesis cisplatin granisetron ABSTRACT Purpose To assess the gelation power of N-palmitoyl L- N-palmitoyl L-alanine organogel alanine derivatives in injectable oils and to use the best chosen organogel as parenteral implant of granisetron for the treat- ment of emesis. ABBREVIATIONS Methods Twelve N-palmitoyl L-alanine derived organogels CGC Critical gelling concentration were developed and evaluated in terms of morphology, ther- DSC Differential scanning calorimetry mal properties and in vivo performance. The ability of the se- GRAS Generally Regarded As Safe lected formula to form in situ gel upon subcutaneous injection H-bond Hydrogen bond in rats and its biocompatibility were monitored over 2 weeks by LA N-lauroyl L-alanine histopathological examination of the injection site. LAM N-lauroyl L-alanine methyl ester Results Theacidderivative(N-palmitoyl L-alanine; PA)was LMWOGs Low molecular weight organogelators superior to ester derivatives. The chosen

Journal

Pharmaceutical ResearchSpringer Journals

Published: May 29, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off