Pharm Res (2018) 35:149 https://doi.org/10.1007/s11095-018-2433-2 RESEARCH PAPER Synthesis, Characterization and Biocompatibility of N-palmitoyl L-alanine-based Organogels as Sustained Implants of Granisetron and Evaluation of thier Antiemetic Effect 1 2 3 3 Hala Bakr El-Nassan & Aliaa Nabil ElMeshad & Walaa Wadie & Rabab H. Sayed Received: 18 March 2018 /Accepted: 18 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 . . . KEY WORDS antiemesis cisplatin granisetron ABSTRACT Purpose To assess the gelation power of N-palmitoyl L- N-palmitoyl L-alanine organogel alanine derivatives in injectable oils and to use the best chosen organogel as parenteral implant of granisetron for the treat- ment of emesis. ABBREVIATIONS Methods Twelve N-palmitoyl L-alanine derived organogels CGC Critical gelling concentration were developed and evaluated in terms of morphology, ther- DSC Differential scanning calorimetry mal properties and in vivo performance. The ability of the se- GRAS Generally Regarded As Safe lected formula to form in situ gel upon subcutaneous injection H-bond Hydrogen bond in rats and its biocompatibility were monitored over 2 weeks by LA N-lauroyl L-alanine histopathological examination of the injection site. LAM N-lauroyl L-alanine methyl ester Results Theacidderivative(N-palmitoyl L-alanine; PA)was LMWOGs Low molecular weight organogelators superior to ester derivatives. The chosen
Pharmaceutical Research – Springer Journals
Published: May 29, 2018
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