Keywords 1,2,3-Triazoles Chromones Antimicrobial activity Molecular docking Introduction The increasing prevalence of infections caused by microorganisms is a major threat across the world, so the development of a diversiﬁed series of biologically active scaffolds is of great interest in drug designing . This includes several popular pharmaceutical drugs such as ﬂuorocytosine, ﬂudarabine, panomifene, and diﬂu- nisal contain ﬂuorine. The introduction of ﬂuorine into a molecule may lead to signiﬁcant inﬂuences on the biological and physical properties of compounds such as metabolic stability, bioavailability, solubility, and lipophilicity . Furthermore, the substitution of ﬂuorine into a potential drug molecule can improve its therapeutic efﬁcacy due to hydrogen bonding interactions at the active sites of enzyme . Interest in chromones continues unabated because of their usefulness as biologically active agents. Some biological activities attributed to chromone derivatives are antitumor , antimicrobial , antioxidant , antiallergic , anti-inﬂammatory , antiplaque , and neuroprotection . Chalcones are the precursors of chromones, and are signiﬁcant pharmacophores exhibiting a variety of biological activities, such as antimalarial , antimicrobial , antiﬁlarial , antioxidant , anti-inﬂammatory , and antiproliferation . 1,2,3-Triazoles emerged as an attractive and desirable scaffold in the develop- ment of potential drug
Research on Chemical Intermediates – Springer Journals
Published: Jun 10, 2016
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