Synthesis, antimicrobial evaluation, and molecular docking studies of novel chromone based 1,2,3-triazoles

Synthesis, antimicrobial evaluation, and molecular docking studies of novel chromone based... Keywords 1,2,3-Triazoles  Chromones  Antimicrobial activity  Molecular docking Introduction The increasing prevalence of infections caused by microorganisms is a major threat across the world, so the development of a diversified series of biologically active scaffolds is of great interest in drug designing [1]. This includes several popular pharmaceutical drugs such as fluorocytosine, fludarabine, panomifene, and diflu- nisal contain fluorine. The introduction of fluorine into a molecule may lead to significant influences on the biological and physical properties of compounds such as metabolic stability, bioavailability, solubility, and lipophilicity [2]. Furthermore, the substitution of fluorine into a potential drug molecule can improve its therapeutic efficacy due to hydrogen bonding interactions at the active sites of enzyme [3]. Interest in chromones continues unabated because of their usefulness as biologically active agents. Some biological activities attributed to chromone derivatives are antitumor [4], antimicrobial [5], antioxidant [6], antiallergic [7], anti-inflammatory [8], antiplaque [9], and neuroprotection [10]. Chalcones are the precursors of chromones, and are significant pharmacophores exhibiting a variety of biological activities, such as antimalarial [11], antimicrobial [12], antifilarial [13], antioxidant [14], anti-inflammatory [15], and antiproliferation [16]. 1,2,3-Triazoles emerged as an attractive and desirable scaffold in the develop- ment of potential drug http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis, antimicrobial evaluation, and molecular docking studies of novel chromone based 1,2,3-triazoles

Loading next page...
 
/lp/springer_journal/synthesis-antimicrobial-evaluation-and-molecular-docking-studies-of-JaeNiZgTur
Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2602-z
Publisher site
See Article on Publisher Site

Abstract

Keywords 1,2,3-Triazoles  Chromones  Antimicrobial activity  Molecular docking Introduction The increasing prevalence of infections caused by microorganisms is a major threat across the world, so the development of a diversified series of biologically active scaffolds is of great interest in drug designing [1]. This includes several popular pharmaceutical drugs such as fluorocytosine, fludarabine, panomifene, and diflu- nisal contain fluorine. The introduction of fluorine into a molecule may lead to significant influences on the biological and physical properties of compounds such as metabolic stability, bioavailability, solubility, and lipophilicity [2]. Furthermore, the substitution of fluorine into a potential drug molecule can improve its therapeutic efficacy due to hydrogen bonding interactions at the active sites of enzyme [3]. Interest in chromones continues unabated because of their usefulness as biologically active agents. Some biological activities attributed to chromone derivatives are antitumor [4], antimicrobial [5], antioxidant [6], antiallergic [7], anti-inflammatory [8], antiplaque [9], and neuroprotection [10]. Chalcones are the precursors of chromones, and are significant pharmacophores exhibiting a variety of biological activities, such as antimalarial [11], antimicrobial [12], antifilarial [13], antioxidant [14], anti-inflammatory [15], and antiproliferation [16]. 1,2,3-Triazoles emerged as an attractive and desirable scaffold in the develop- ment of potential drug

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jun 10, 2016

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off