Synthesis, antimicrobial evaluation, and molecular docking studies of novel chromone based 1,2,3-triazoles

Synthesis, antimicrobial evaluation, and molecular docking studies of novel chromone based... Keywords 1,2,3-Triazoles  Chromones  Antimicrobial activity  Molecular docking Introduction The increasing prevalence of infections caused by microorganisms is a major threat across the world, so the development of a diversified series of biologically active scaffolds is of great interest in drug designing [1]. This includes several popular pharmaceutical drugs such as fluorocytosine, fludarabine, panomifene, and diflu- nisal contain fluorine. The introduction of fluorine into a molecule may lead to significant influences on the biological and physical properties of compounds such as metabolic stability, bioavailability, solubility, and lipophilicity [2]. Furthermore, the substitution of fluorine into a potential drug molecule can improve its therapeutic efficacy due to hydrogen bonding interactions at the active sites of enzyme [3]. Interest in chromones continues unabated because of their usefulness as biologically active agents. Some biological activities attributed to chromone derivatives are antitumor [4], antimicrobial [5], antioxidant [6], antiallergic [7], anti-inflammatory [8], antiplaque [9], and neuroprotection [10]. Chalcones are the precursors of chromones, and are significant pharmacophores exhibiting a variety of biological activities, such as antimalarial [11], antimicrobial [12], antifilarial [13], antioxidant [14], anti-inflammatory [15], and antiproliferation [16]. 1,2,3-Triazoles emerged as an attractive and desirable scaffold in the develop- ment of potential drug http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis, antimicrobial evaluation, and molecular docking studies of novel chromone based 1,2,3-triazoles

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Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2602-z
Publisher site
See Article on Publisher Site

Abstract

Keywords 1,2,3-Triazoles  Chromones  Antimicrobial activity  Molecular docking Introduction The increasing prevalence of infections caused by microorganisms is a major threat across the world, so the development of a diversified series of biologically active scaffolds is of great interest in drug designing [1]. This includes several popular pharmaceutical drugs such as fluorocytosine, fludarabine, panomifene, and diflu- nisal contain fluorine. The introduction of fluorine into a molecule may lead to significant influences on the biological and physical properties of compounds such as metabolic stability, bioavailability, solubility, and lipophilicity [2]. Furthermore, the substitution of fluorine into a potential drug molecule can improve its therapeutic efficacy due to hydrogen bonding interactions at the active sites of enzyme [3]. Interest in chromones continues unabated because of their usefulness as biologically active agents. Some biological activities attributed to chromone derivatives are antitumor [4], antimicrobial [5], antioxidant [6], antiallergic [7], anti-inflammatory [8], antiplaque [9], and neuroprotection [10]. Chalcones are the precursors of chromones, and are significant pharmacophores exhibiting a variety of biological activities, such as antimalarial [11], antimicrobial [12], antifilarial [13], antioxidant [14], anti-inflammatory [15], and antiproliferation [16]. 1,2,3-Triazoles emerged as an attractive and desirable scaffold in the develop- ment of potential drug

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jun 10, 2016

References

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