Access the full text.
Sign up today, get DeepDyve free for 14 days.
Dai Kubota, M. Ishikawa, Mikio Yamamoto, Shoichi Murakami, M. Hachisu, K. Katano, K. Ajito (2006)
Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting αvβ3/αIIbβ3 dual antagonistic activityBioorganic & Medicinal Chemistry, 14
E. Brandt, R. Strait, D. Hershko, Quan Wang, E. Muntel, Troy Scribner, N. Zimmermann, F. Finkelman, M. Rothenberg (2003)
Mast cells are required for experimental oral allergen-induced diarrhea.The Journal of clinical investigation, 112 11
G. Rauhut, Steve Puyear, A. Woliński, P. Pulay (1996)
Comparison of NMR Shieldings Calculated from Hartree−Fock and Density Functional Wave Functions Using Gauge-Including Atomic OrbitalsThe Journal of Physical Chemistry, 100
W. Hieringer, F. Sala, A. Görling (2004)
Density-functional calculations of NMR shielding constants using the localized Hartree–Fock methodChemical Physics Letters, 383
C. Jamorski, M. Casida, D. Salahub (1996)
Dynamic polarizabilities and excitation spectra from a molecular implementation of time‐dependent density‐functional response theory: N2 as a case studyJournal of Chemical Physics, 104
S. Kuo, S. Tsai, H. Li, C. Wu, K. Ishii, H. Nakamura (1988)
Studies on heterocyclic compounds. IX. Synthesis and antiallergic activity of furo[2,3-b] [1,8]naphthyridine-3,4(2H,9H)-diones and 4H-furo[2,3-d]pyrido [1,2-alpha]-pyrimidine-3,4(2H)-diones.Chemical & pharmaceutical bulletin, 36 11
M. Ishikawa, Dai Kubota, Mikio Yamamoto, Chizuko Kuroda, M. Iguchi, A. Koyanagi, Shoichi Murakami, K. Ajito (2006)
Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part 2: Synthesis of potent αvβ3/αIIbβ3 dual antagonistsBioorganic & Medicinal Chemistry, 14
Y. Hamasaki, M. Zaitu, K. Tsuji, M. Miyazaki, R. Hayasaki, E. Muro, S. Yamamoto, I. Kobayashi, M. Matsuo, T. Ichimaru, S. Miyazaki (2000)
(9-[4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido [1,2-a] pyrimidin-4-one), AS-35, inhibits leukotriene synthesis.International journal of immunopharmacology, 22 7
Russell Hopp, A. Bewtra, N. Nair, Robert Townley (1985)
The effect of age on methacholine response.The Journal of allergy and clinical immunology, 76 4
(2004)
Allergy Clin. Immunol
B. Suhagia, M. Chhabria, A. Makwana (2006)
Design, synthesis and pharmacological screening of a series of N1-(substituted)aryl-5,7-dimethyl-2-(substituted)pyrido(2,3-d)pyrimidin-4(3H)-ones as potential histamine H1-receptor antagonistsJournal of Enzyme Inhibition and Medicinal Chemistry, 21
R. Bauernschmitt, R. Ahlrichs (1996)
Treatment of electronic excitations within the adiabatic approximation of time dependent density functional theoryChemical Physics Letters, 256
D. Connor, R. Sorenson, W. Cetenko, J. Kerbleski, F. Tinney (1984)
Synthesis and antiallergy activity of 10-oxo-10H-pyrido[1,2-a]thieno[3,2-d]pyrimidines and 10-oxo-10H-pyrido[1,2-a]thieno[3,4-d]pyrimidines.Journal of medicinal chemistry, 27 4
R. Bauernschmitt, Marco Häser, Oliver Treutler, R. Ahlrichs (1997)
CALCULATION OF EXCITATION ENERGIES WITHIN TIME-DEPENDENT DENSITY FUNCTIONAL THEORY USING AUXILIARY BASIS SET EXPANSIONSChemical Physics Letters, 264
K. Gyires, S. Fürst, I. Miklya, I. Budavári, J. Knoll (1985)
Analysis of the analgesic and anti-inflammatory effects of rimazolium, a pyrido-pyrimidine derivative, compared with that of prostaglandin synthesis inhibitors and morphine.Drugs under experimental and clinical research, 11 8
(2000)
The relaxant effect of test materials on contractions of guinea pig tracheal chain induced by histamine
A. Carr, D. Meyer (1983)
Synthesis of terfenadine.Arzneimittel-Forschung, 32 9a
K. Simons, M. Benedetti, F. Simons, M. Gillard, E. Baltès (2007)
Relevance of H1-receptor occupancy to H1-antihistamine dosing in children.The Journal of allergy and clinical immunology, 119 6
W. Moore, R. Webber, K. Fok, G. Jerome, J. Connor, P. Manning, P. Wyatt, T. Misko, F. Tjoeng, M. Currie (1996)
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.Journal of medicinal chemistry, 39 3
G. Leoncini, M. Signorello, G. Roma, M. Braccio (1997)
Effect of 2-(1-piperazinyl)-4H-pyrido[1,2-a]pyrimidin-4-one (AP155) on human platelets in vitro.Biochemical pharmacology, 53 11
A. Hirabayashi, H. Mukaiyama, Hiroaki Kobayashi, H. Shiohara, S. Nakayama, Motoyasu Ozawa, E. Tsuji, K. Miyazawa, Keiko Misawa, H. Ohnota, M. Isaji (2008)
Structure-activity relationship studies of imidazo[1,2-c]pyrimidine derivatives as potent and orally effective Syk family kinases inhibitors.Bioorganic & medicinal chemistry, 16 20
K. Sztanke, K. Pasternak, A. Sidor-Wójtowicz, J. Truchlińska, K. Jóźwiak (2006)
Synthesis of imidazoline and imidazo[2,1-c][1,2,4]triazole aryl derivatives containing the methylthio group as possible antibacterial agents.Bioorganic & medicinal chemistry, 14 11
E. Kowaluk, J. Mikusa, C. Wismer, C. Zhu, E. Schweitzer, J. Lynch, C. Lee, M. Jiang, S. Bhagwat, A. Gomtsyan, J. McKie, B. Cox, J. Polakowski, G. Reinhart, M. Williams, M. Jarvis (2000)
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat.The Journal of pharmacology and experimental therapeutics, 295 3
K. Atwal, S. Moreland (1991)
Dihydropyrimidine calcium channel blockers 51: bicyclic dihydropyrimidines as potent mimics of dihydropyridinesBioorganic & Medicinal Chemistry Letters, 1
G. Roma, M. Braccio, G. Leoncini, B. Aprile (1993)
1,2-fused pyrimidines. VI. Substituted 2-amino-4H-pyrido[1,2-a]pyrimidin-4-ones with antiplatelet activity.Farmaco, 48 9
M. Ashenager, T. Grgela, Y. Aragane, A. Kawada (2007)
Inhibition of cytokine-induced expression of T-cell cytokines by antihistamines.Journal of investigational allergology & clinical immunology, 17 1
Y. Shao, Yong Ding, Zhao-Li Jia, Xiao-min Lu, Zhilong Ke, Weihong Xu, Guoyuan Lu (2009)
Synthesis and DNA cleavage activity of 2-hydrazinyl-1,4,5,6-tetrahydropyrimidine containing hydroxy group.Bioorganic & medicinal chemistry, 17 13
M. Youssouf, Peerzada Kaiser, G. Singh, S. Singh, S. Bani, V. Gupta, N. Satti, K. Suri, R. Johri (2008)
Anti-histaminic, anti-inflammatory and bronchorelaxant activities of 2, 7-dimethyl-3-nitro-4H pyrido [1,2-a] pyrimidine-4-one.International immunopharmacology, 8 7
A. Wood, F. Simons, K. Simons (1994)
The pharmacology and use of H1-receptor-antagonist drugs.The New England journal of medicine, 330 23
A. Zarrouk, B. Hammouti, H. Zarrok, R. Salghi, M. Bouachrine, F. Bentiss, S. Al-Deyab (2012)
Theoretical study using DFT calculations on inhibitory action of four pyridazines on corrosion of copper in nitric acidResearch on Chemical Intermediates, 38
N. Tokay, Z. Seferoğlu, C. Öǧretir, N. Ertan (2008)
Quantum chemical studies on the structures of some heterocyclic azo disperse dyesArkivoc, 2008
F. Sala, A. Görling (2001)
Efficient localized Hartree-Fock methods as effective exact-exchange Kohn-Sham methods for moleculesJournal of Chemical Physics, 115
P. Molina, E. Aller, Á. Lorenzo, P. López-Cremades, I. Rioja, A. Úbeda, M. Terencio, M. Alcaraz (2001)
Solid-phase synthesis and inhibitory effects of some pyrido[1,2-c]pyrimidine derivatives on leukocyte formations and experimental inflammation.Journal of medicinal chemistry, 44 6
J. Chang-Fong, K. Benamour, B. Szymonski, F. Thomasson, J. Morand, M. Cussac (2000)
Synthesis and alpha-adrenergic binding ligand affinities of 2-iminoimidazolidine derivatives.Chemical & pharmaceutical bulletin, 48 5
N. Chairungsrilerd, K. Furukawa, T. Ohta, S. Nozoe, Y. Ohizumi (1996)
Pharmacological properties of α-mangostin, a novel histamine H1 receptor antagonistEuropean Journal of Pharmacology, 314
I. Althaus, K. Chou, R. Lemay, K. Franks, M. Deibel, F. Kézdy, L. Resnick, M. Busso, A. So, K. Downey, D. Romero, R. Thomas, P. Aristoff, W. Tarpley, F. Reusser (1996)
The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase.Biochemical pharmacology, 51 6
In this study, (4-methoxybenzyl)(1,4,5,6-tetrahydropyrimidin-2-yl)amine hydroiodide (2) was synthesized by reaction of 2-methylmercapto-1,4,5,6-tetrahydropyrimidine hydroiodide (1) and 4-methoxybenzylamine. The synthesized compound was tested for its in vitro H1-antihistaminic activity on guinea pig trachea. A promising bronchorelaxant effect of 2 was observed in histamine-contracted guinea pig tracheal chain via H1 receptor antagonism. In addition, the molecular geometry and gauge including atomic orbital (GIAO) 1H chemical shift values of the title compound in the ground state were calculated using the density functional method (DFT/UB3LYP) and Hartree–Fock (HF) approach using 6–311G+(d), 6–311G+(d,p), LANL2DZ, DGDZVP, and DGDZVP2 basis sets and compared with the experimental data. According to the experimental and theoretical results, HF/6–311G+(d) showed a better fit to experimental values in evaluating 1H-nuclear magnetic resonance (NMR) chemical shift values. Theoretical studies supported our findings, revealing the N12 atom as the most nucleophilic. In addition, other structures of the compound such as the aromatic ring and OCH3 group increased this property.
Research on Chemical Intermediates – Springer Journals
Published: Sep 29, 2012
Access the full text.
Sign up today, get DeepDyve free for 14 days.