Synthesis, antibacterial activity against MRSA, and in vitro cytotoxic activity against HeLa cell lines of novel 3-α-carboxy ethyl-5-benzylidene rhodanine derivatives

Synthesis, antibacterial activity against MRSA, and in vitro cytotoxic activity against HeLa cell... A series of novel 3-α-carboxy ethyl-5-benzylidene rhodanines, 3a–h, has been accomplished by Knoevenagel condensation with 3-α-carboxy ethyl rhodanine and various substituted aromatic aldehydes. All the synthesized compounds 3a–h were confirmed by spectroscopic techniques. The cytotoxic studies of compounds 3a–h were performed against human cervical cancer cell line (HeLa) by MTT assay. Further, the compounds 3a–h were also screened for their antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). SAR study was carried out for the in vitro cytotoxic studies against HeLa cell lines and antibacterial activity against MRSA. The results suggested that this series of compounds could serve as the basis for the development of novel anticancer and antimicrobial agents. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis, antibacterial activity against MRSA, and in vitro cytotoxic activity against HeLa cell lines of novel 3-α-carboxy ethyl-5-benzylidene rhodanine derivatives

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Publisher
Springer Netherlands
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1251-8
Publisher site
See Article on Publisher Site

Abstract

A series of novel 3-α-carboxy ethyl-5-benzylidene rhodanines, 3a–h, has been accomplished by Knoevenagel condensation with 3-α-carboxy ethyl rhodanine and various substituted aromatic aldehydes. All the synthesized compounds 3a–h were confirmed by spectroscopic techniques. The cytotoxic studies of compounds 3a–h were performed against human cervical cancer cell line (HeLa) by MTT assay. Further, the compounds 3a–h were also screened for their antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). SAR study was carried out for the in vitro cytotoxic studies against HeLa cell lines and antibacterial activity against MRSA. The results suggested that this series of compounds could serve as the basis for the development of novel anticancer and antimicrobial agents.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: May 24, 2013

References

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