A series of novel 3-α-carboxy ethyl-5-benzylidene rhodanines, 3a–h, has been accomplished by Knoevenagel condensation with 3-α-carboxy ethyl rhodanine and various substituted aromatic aldehydes. All the synthesized compounds 3a–h were confirmed by spectroscopic techniques. The cytotoxic studies of compounds 3a–h were performed against human cervical cancer cell line (HeLa) by MTT assay. Further, the compounds 3a–h were also screened for their antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). SAR study was carried out for the in vitro cytotoxic studies against HeLa cell lines and antibacterial activity against MRSA. The results suggested that this series of compounds could serve as the basis for the development of novel anticancer and antimicrobial agents.
Research on Chemical Intermediates – Springer Journals
Published: May 24, 2013
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