Six new adipic (adipH2) and sebacic (sebacH2) complexes of silver(I), gold(III), and platinum(IV) ions in the presence of selenium metal; [(adip)Ag2Se2O2(OH)4Cl2] (1), [(adip)Au2Cl4Se2O2(OH)4Cl2] (2), [(adip)Pt2Cl6(H2O)2Se2O2(OH)4Cl2] (3), [(sebac)Ag2Se2O2(OH)4Cl2] (4), [(sebac)Au2Cl4Se2O2(OH)4Cl2] (5), and [(sebac)Pt2Cl6 (H2O)2Se2O2(OH)4Cl2] (6) were designed and synthesized to enhance the biological treatments against bacteria, fungi, and cancer cells. The adip and sebac complexes were screened for antibacterial and antifungal activities. Adipic, sebacic acid, and their complexes were subjected to cytotoxicity evaluation against Ehrlich ascites carcinoma cell line by trypan blue assay. Biochemical parameters included activity of glutathione-S-transferase, while reduced glutathione levels and malondialdehyde levels which corresponded to cytotoxicity effects of tested compounds were evaluated. Also, spleen cytotoxicity was evaluated for bio-safety purpose.
Research on Chemical Intermediates – Springer Journals
Published: May 15, 2013
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