Synthesis and spectroscopic characterizations of noble metal complexes (gold, silver, platinum) in the presence of selenium, and their biological applications as antibacterial, antifungal, and anticancer

Synthesis and spectroscopic characterizations of noble metal complexes (gold, silver, platinum)... Six new adipic (adipH2) and sebacic (sebacH2) complexes of silver(I), gold(III), and platinum(IV) ions in the presence of selenium metal; [(adip)Ag2Se2O2(OH)4Cl2] (1), [(adip)Au2Cl4Se2O2(OH)4Cl2] (2), [(adip)Pt2Cl6(H2O)2Se2O2(OH)4Cl2] (3), [(sebac)Ag2Se2O2(OH)4Cl2] (4), [(sebac)Au2Cl4Se2O2(OH)4Cl2] (5), and [(sebac)Pt2Cl6 (H2O)2Se2O2(OH)4Cl2] (6) were designed and synthesized to enhance the biological treatments against bacteria, fungi, and cancer cells. The adip and sebac complexes were screened for antibacterial and antifungal activities. Adipic, sebacic acid, and their complexes were subjected to cytotoxicity evaluation against Ehrlich ascites carcinoma cell line by trypan blue assay. Biochemical parameters included activity of glutathione-S-transferase, while reduced glutathione levels and malondialdehyde levels which corresponded to cytotoxicity effects of tested compounds were evaluated. Also, spleen cytotoxicity was evaluated for bio-safety purpose. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis and spectroscopic characterizations of noble metal complexes (gold, silver, platinum) in the presence of selenium, and their biological applications as antibacterial, antifungal, and anticancer

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Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1249-2
Publisher site
See Article on Publisher Site

Abstract

Six new adipic (adipH2) and sebacic (sebacH2) complexes of silver(I), gold(III), and platinum(IV) ions in the presence of selenium metal; [(adip)Ag2Se2O2(OH)4Cl2] (1), [(adip)Au2Cl4Se2O2(OH)4Cl2] (2), [(adip)Pt2Cl6(H2O)2Se2O2(OH)4Cl2] (3), [(sebac)Ag2Se2O2(OH)4Cl2] (4), [(sebac)Au2Cl4Se2O2(OH)4Cl2] (5), and [(sebac)Pt2Cl6 (H2O)2Se2O2(OH)4Cl2] (6) were designed and synthesized to enhance the biological treatments against bacteria, fungi, and cancer cells. The adip and sebac complexes were screened for antibacterial and antifungal activities. Adipic, sebacic acid, and their complexes were subjected to cytotoxicity evaluation against Ehrlich ascites carcinoma cell line by trypan blue assay. Biochemical parameters included activity of glutathione-S-transferase, while reduced glutathione levels and malondialdehyde levels which corresponded to cytotoxicity effects of tested compounds were evaluated. Also, spleen cytotoxicity was evaluated for bio-safety purpose.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: May 15, 2013

References

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