1070-4272/05/7804-0636 C 2005 Pleiades Publishing, Inc.
Russian Journal of Applied Chemistry, Vol. 78, No. 4, 2005, pp. 636!640. Translated from Zhurnal Prikladnoi Khimii, Vol. 78, No. 4, 2005,
Original Russian Text Copyright + 2005 by Solovskii, Tarabukina, Shpyrkov, Denisov, Vlasova, Korchagin.
AND POLYMERIC MATERIALS
Synthesis and Properties of Soluble Copolymers
of N-Vinyl-2-pyrrolidone with 2-Hydroxyethyl Methacrylate
M. V. Solovskii, E. B. Tarabukina, A. A. Shpyrkov, V. M. Denisov,
E. N. Vlasova, and A. M. Korchagin
Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russia
Received December 29, 2004
Abstract-Features of radical copolymerization of N-vinyl-2-pyrrolidone with 2-hydroxyethyl methacrylate
in the presence of azobis(isobutyronitrile) were studied. The copolymerization constants of these monomers
were calculated. The structure of the resulting copolymer was confirmed. The composition, microstructure,
and molecular-weight parameters of the copolymers were determined.
Polymeric N-vinylpyrrolidone (VP), polyvinylpyr-
rolidone, is widely used in medicine as detoxicant 
and modifier of morphine, iodine , and silver .
VP copolymers are studied as carriers for antimicro-
bial , hormone-containing , and other pharmaceu-
ticals  and haptens . At the same time, poly-(2-
hydroxyethyl methacrylate) (HEMA) exhibits a num-
ber of valuable medical and biological properties: its
hydrogels can be used to immobilize various pharma-
ceuticals  and to produce contact lenses .
VP3HEMA copolymers with a combination of VP
and HEMA units can be used as carriers of bio-
logically active compounds since they are hydro-
philic, low toxic, and biocompatible with blood and
tissues of a living body. These properties are provided
by primary hydroxy groups in the side unit of the co-
At the same time, features of copolymerization
of VP and HEMA and the microstructure and molec-
ular-weight parameters of VP3HEMA copolymers are
poorly understood. Here we studied these issues.
As can be seen from Fig. 1a, the copolymerization
rate strongly depends on the initial concentration of
the monomer mixture. The higher this concentration,
the faster the copolymerization. The copolymerization
of VP with HEMA in isopropanol (Fig. 1b) also ac-
celerates as the HEMA concentration [M
] in the ini-
tial mixture becomes higher, which indicates that
) is more reactive than VP in copoly-
In the first copolymerization steps, the concentra-
tion of HEMA (M
) units in the copolymer is substan-
tially higher than the HEMA concentration in the ini-
tial mixture. In the course of copolymerization, this
Fig. 1. Monomer conversion K in copolymerization of VP with HEMA in isopropanol at 60oC vs. time t. (a) [AIBN] =
4.5 wt %, [M
] (wt %): (1) 10, (2) 20, and (3) 30. (b) [AIBN] = 1.5 wt %, [M
] = 20 wt %. [M
] (mol %): (1) 75 : 25 and (2) 80 : 20.