Here we describe the synthesis and in vitro anticancer activity of three bi-functional 1,8-naphthalimide N (4) and S (4)-derivatives presenting both DNA intercalation and alkylation capabilities. Cell viability assays indicate that these amonafide- N -mustard chimeras are effective only on certain tumor cell lines and are less toxic towards non-malignant cells than their parent drug: amonafide.(Figure not available: see fulltext.)
Research on Chemical Intermediates – Springer Journals
Published: Jun 2, 2015
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