Synthesis and in vitro anticancer evaluation of 1,8-naphthalimide N(4) and S(4)-derivatives combining DNA intercalation and alkylation capabilities

Synthesis and in vitro anticancer evaluation of 1,8-naphthalimide N(4) and S(4)-derivatives... Here we describe the synthesis and in vitro anticancer activity of three bi-functional 1,8-naphthalimide N (4) and S (4)-derivatives presenting both DNA intercalation and alkylation capabilities. Cell viability assays indicate that these amonafide- N -mustard chimeras are effective only on certain tumor cell lines and are less toxic towards non-malignant cells than their parent drug: amonafide.(Figure not available: see fulltext.) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis and in vitro anticancer evaluation of 1,8-naphthalimide N(4) and S(4)-derivatives combining DNA intercalation and alkylation capabilities

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Publisher
Springer Netherlands
Copyright
Copyright © 2015 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-015-2115-1
Publisher site
See Article on Publisher Site

Abstract

Here we describe the synthesis and in vitro anticancer activity of three bi-functional 1,8-naphthalimide N (4) and S (4)-derivatives presenting both DNA intercalation and alkylation capabilities. Cell viability assays indicate that these amonafide- N -mustard chimeras are effective only on certain tumor cell lines and are less toxic towards non-malignant cells than their parent drug: amonafide.(Figure not available: see fulltext.)

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jun 2, 2015

References

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