Keywords Lopinavir intermediate Isocyanates Isothiocyanates Antimicrobial and antioxidant activity Molecular docking studies Introduction HIV-1 protease inhibitors have emerged as some of the most powerful anti-HIV drugs reported to date, and they are the main components of highly active antiretroviral therapy (HAART) [1, 2]. Currently, there are nine HIV-1 protease inhibitors FDA approved for the effective treatment of AIDS, and some are marked darunavir (DRV) (1), ritonavir RTV) (2), lopinavir (LPV) (3), and amprenavir (APV) (4), as shown in Fig. 1. All these drugs are competitive inhibitors that bind in the active site of the enzyme . Among the HIV aspartyl protease inhibitors, lopinavir is highly potent and plays a critical role in the conversion of viral Gag and O O NH H O N N N O O OH S N OH Ritonavir (RTV) NH O N N N NH O N OH O OH Amprenavir (APV) Lopinavir (LPV) Fig. 1 Important HIV-1 protease inhibitors Darunavir (DRV) Cysteine protease inhibition by lopinavir intermediate 105 Gag–Pol polyproteins into structural and functional proteins, which are essential for viral maturation in the virus life cycle . The treatment of bacterial infections is a challenging therapeutic problem in the
Research on Chemical Intermediates – Springer Journals
Published: Jun 20, 2016
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