derivatives were obtained via [3 ? 3]-cyclization of 4-amino-5H-thiazol-2-one and a,b-unsaturated ketones or a-ketoacids. The structures of newly synthesized com- pounds were established by spectral data and a single- crystal X-ray diffraction analysis. Target compounds were screened for their anticancer activity according to US NCI protocols and moderate inhibitory activity against the tes- ted cell line was conﬁrmed. 5-Phenyl-7-(pyridin-3-yl)-3H- Keywords 4-Amino-5H-thiazol-2-one Thiazolo[4,5- thiazolo[4,5-b]pyridin-2-one (3) and 2-oxo-7-thiophen-2- b]pyridin-2(3H)-one X-ray study Cell lines HepG2 yl-2,3-dihydrothiazolo[4,5-b]pyridine-5-carboxylic acid Balb/c 3T3 (12) were screened for their cytotoxicity effects on HepG2 and Balb/c 3T3 cells which revealed promising results using MTT, NRU and TPC assays. Introduction Among condensed pyridine derivatives, it has been drawn a considerable attention and interest to thiazolo[4,5- b]pyridines due to their diverse biological activity and clinical applications. Thus, thiazolopyridine derivatives have shown a broad range of interesting biological activi- ties, such as analgesic, antioxidant, antiinﬂammatory, anticancer, antifungal, and herbicidal properties (Chaban Electronic supplementary material The online version of this article (doi:10.1007/s11696-017-0318-1) contains supplementary et al. 2013, 2016; Hegde and Mahoney 1993; El-Gaby et al. material, which is available to authorized users. 2006). Moreover, thiazolo[4,5-b]pyridines are well-known as ErbB family of tyrosine kinase (EGFR) inhibitors (Lin & Roman
Chemical Papers – Springer Journals
Published: Oct 16, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera