A series of some new 1,2-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl)-ethane derivatives 3–18 were designed and synthesized from succinic acid via conventional heating and microwave (MW) irradiation. A benign synthesis was planned so as to take the advantages of Microwave Assisted Organic Synthesis technique. Better yields and shorter reaction times were realized using MW. The structures of the prepared compounds have been elucidated unambiguously by FT-IR, 1H/13C Nuclear Magnetic Resonance (NMR)-spectroscopic methods including HH-Correlation Spectroscopy (COSY), Heteronuclear Single Quantum Spectroscopy (HSQC) and Heteronuclear Multiple-Bond Spectroscopy (HMBC) experiments. Results of the minimal inhibitory concentration for some selected compounds exhibited potential activity against both bacteria and fungi, comparing with the standard drugs Cefotaxime and Nystatin.
Research on Chemical Intermediates – Springer Journals
Published: Apr 8, 2016
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