Synthesis and crystal structure of 1,3-dihydro-4-(2-hydroxyethyl)-2H-indol-2-one

Synthesis and crystal structure of 1,3-dihydro-4-(2-hydroxyethyl)-2H-indol-2-one 1,3-dihydro-4-(2-hydroxyethyl)-2H-indol-2-one, an important intermediate in the synthesis of ropinirole, was synthesized, characterized by IR, 1H NMR, 13C NMR and element analysis, and the crystal structure was confirmed by X-ray crystal structure analysis. This compound crystallizes in the monoclinic class space group P21/c with cell parameters, a = 7.3830(15) Å, b = 12.318(3) Å, c = 9.4801(19)(8) Å; β = 92.76(3)º, and Z = 4. The structure exhibits intermolecular hydrogen bonds and weak π···π interaction leading to the formation of a three-dimensional network structure. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis and crystal structure of 1,3-dihydro-4-(2-hydroxyethyl)-2H-indol-2-one

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Publisher
Springer Netherlands
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1368-9
Publisher site
See Article on Publisher Site

Abstract

1,3-dihydro-4-(2-hydroxyethyl)-2H-indol-2-one, an important intermediate in the synthesis of ropinirole, was synthesized, characterized by IR, 1H NMR, 13C NMR and element analysis, and the crystal structure was confirmed by X-ray crystal structure analysis. This compound crystallizes in the monoclinic class space group P21/c with cell parameters, a = 7.3830(15) Å, b = 12.318(3) Å, c = 9.4801(19)(8) Å; β = 92.76(3)º, and Z = 4. The structure exhibits intermolecular hydrogen bonds and weak π···π interaction leading to the formation of a three-dimensional network structure.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Aug 27, 2013

References

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