Synthesis and characterization of novel benzothiazole amide derivatives and screening as possible antimitotic and antimicrobial agents

Synthesis and characterization of novel benzothiazole amide derivatives and screening as possible... Keywords Benzothiazole  Amide  HATU  Antimitotic activity  Allium assay Introduction The main cause of development of cancer is continuous, unregulated proliferation of cells; rather than responding appropriately to signals that control normal cell behavior, cancer cells grow and divide in an uncontrolled manner in tissues or organs. Any substance capable of arresting the process of cell division is known as an antimitotic drug. In literature, it is reported that some 2-substituted benzothia- zoles exhibit moderate antimitotic activity [1]. Literature survey reveals that nitrogen- and sulfur-containing compounds show very good bioactivity, being potentially active against cancer as well as viral and fungal diseases [2, 3]. Heterocyclic compounds conjugated with amino acids have proven to be potentially active against various diseases, and many of them have seen wide acceptance in clinical trials [4, 5]. Moreover, the amide moiety has attracted further interest because it is widespread in natural and synthetic drugs and shows lower toxicity [6]. Bioactivity of amides can also be achieved by constructing the amide with benzothiazole. Benzothiazole is a heterocyclic compound that is a weak base, having various biological activities [7, 8]. The basic structure of benzothiazole consists of a benzene ring fused at 4,5-position http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis and characterization of novel benzothiazole amide derivatives and screening as possible antimitotic and antimicrobial agents

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Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2627-3
Publisher site
See Article on Publisher Site

Abstract

Keywords Benzothiazole  Amide  HATU  Antimitotic activity  Allium assay Introduction The main cause of development of cancer is continuous, unregulated proliferation of cells; rather than responding appropriately to signals that control normal cell behavior, cancer cells grow and divide in an uncontrolled manner in tissues or organs. Any substance capable of arresting the process of cell division is known as an antimitotic drug. In literature, it is reported that some 2-substituted benzothia- zoles exhibit moderate antimitotic activity [1]. Literature survey reveals that nitrogen- and sulfur-containing compounds show very good bioactivity, being potentially active against cancer as well as viral and fungal diseases [2, 3]. Heterocyclic compounds conjugated with amino acids have proven to be potentially active against various diseases, and many of them have seen wide acceptance in clinical trials [4, 5]. Moreover, the amide moiety has attracted further interest because it is widespread in natural and synthetic drugs and shows lower toxicity [6]. Bioactivity of amides can also be achieved by constructing the amide with benzothiazole. Benzothiazole is a heterocyclic compound that is a weak base, having various biological activities [7, 8]. The basic structure of benzothiazole consists of a benzene ring fused at 4,5-position

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jul 6, 2016

References

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