Keywords Antitubercular activity Anti-oxidant activity 1,2,3-Triazoles Biscoumarins Molecular docking Introduction The coumarin moiety has been used as a pharmacophore unit for the last two centuries. Many drugs bearing the coumarin moiety are used as anticoagulants, antibiotics, insecticides and pesticides. Synthetic organic chemists and biologists have paid attention to the synthesis of coumarin derivatives, because they exhibit various biological activities such as anticancer , anti-breast cancer , anti- Alzheimers , anti-oxidant , anti-inﬂuenza , antidepressant , antihepatitis C, anti-inﬂammatory  and antitubercular . Synthetic and naturally occurring biscoumarin scaffolds have attracted considerable attention in medicinal chemistry. The biscoumarin derivatives are of biological importance because of their ability to form hydrogen bonding via two hydroxyl groups and show various biological activities including a-glucosidase , anticoagulant , antimicrobial , (HIV-1 IN) inhibitor , urease inhibitors , enzyme inhibitory activity , antibacterial, antitumor , anti-oxidant  and c-Met inhibitors . Synthesis of coumarin fused or linked with different heterocyclic derivatives has been gaining importance over the last few decades in medical and chemical research . The term, ‘‘Click Chemistry’’ was introduced for the ﬁrst time by the Sharpless research group . It is a 1,3-dipolar cycloaddition reaction between alkyne and
Research on Chemical Intermediates – Springer Journals
Published: May 31, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera