Synthesis and biological evaluation of novel triazole-biscoumarin conjugates as potential antitubercular and anti-oxidant agents

Synthesis and biological evaluation of novel triazole-biscoumarin conjugates as potential... Keywords Antitubercular activity  Anti-oxidant activity  1,2,3-Triazoles Biscoumarins  Molecular docking Introduction The coumarin moiety has been used as a pharmacophore unit for the last two centuries. Many drugs bearing the coumarin moiety are used as anticoagulants, antibiotics, insecticides and pesticides. Synthetic organic chemists and biologists have paid attention to the synthesis of coumarin derivatives, because they exhibit various biological activities such as anticancer [1], anti-breast cancer [2], anti- Alzheimers [3], anti-oxidant [4], anti-influenza [5], antidepressant [6], antihepatitis C[7], anti-inflammatory [8] and antitubercular [9]. Synthetic and naturally occurring biscoumarin scaffolds have attracted considerable attention in medicinal chemistry. The biscoumarin derivatives are of biological importance because of their ability to form hydrogen bonding via two hydroxyl groups and show various biological activities including a-glucosidase [10], anticoagulant [11], antimicrobial [12], (HIV-1 IN) inhibitor [13], urease inhibitors [14], enzyme inhibitory activity [15], antibacterial, antitumor [16], anti-oxidant [17] and c-Met inhibitors [18]. Synthesis of coumarin fused or linked with different heterocyclic derivatives has been gaining importance over the last few decades in medical and chemical research [19]. The term, ‘‘Click Chemistry’’ was introduced for the first time by the Sharpless research group [20]. It is a 1,3-dipolar cycloaddition reaction between alkyne and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis and biological evaluation of novel triazole-biscoumarin conjugates as potential antitubercular and anti-oxidant agents

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Publisher
Springer Netherlands
Copyright
Copyright © 2018 by Springer Science+Business Media B.V., part of Springer Nature
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-018-3490-1
Publisher site
See Article on Publisher Site

Abstract

Keywords Antitubercular activity  Anti-oxidant activity  1,2,3-Triazoles Biscoumarins  Molecular docking Introduction The coumarin moiety has been used as a pharmacophore unit for the last two centuries. Many drugs bearing the coumarin moiety are used as anticoagulants, antibiotics, insecticides and pesticides. Synthetic organic chemists and biologists have paid attention to the synthesis of coumarin derivatives, because they exhibit various biological activities such as anticancer [1], anti-breast cancer [2], anti- Alzheimers [3], anti-oxidant [4], anti-influenza [5], antidepressant [6], antihepatitis C[7], anti-inflammatory [8] and antitubercular [9]. Synthetic and naturally occurring biscoumarin scaffolds have attracted considerable attention in medicinal chemistry. The biscoumarin derivatives are of biological importance because of their ability to form hydrogen bonding via two hydroxyl groups and show various biological activities including a-glucosidase [10], anticoagulant [11], antimicrobial [12], (HIV-1 IN) inhibitor [13], urease inhibitors [14], enzyme inhibitory activity [15], antibacterial, antitumor [16], anti-oxidant [17] and c-Met inhibitors [18]. Synthesis of coumarin fused or linked with different heterocyclic derivatives has been gaining importance over the last few decades in medical and chemical research [19]. The term, ‘‘Click Chemistry’’ was introduced for the first time by the Sharpless research group [20]. It is a 1,3-dipolar cycloaddition reaction between alkyne and

Journal

Research on Chemical IntermediatesSpringer Journals

Published: May 31, 2018

References

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