Synthesis and biological evaluation of new series 1,4-
Seyedeh Mina Malaekehpoor
Received: 5 August 2015 / Accepted: 28 September 2015 / Published online: 26 October 2015
Ó Springer Science+Business Media Dordrecht 2015
-Tetrachlorobenzene-1,3-disulfonamide and poly(N,N
N-ethyl-benzene-1,3-disulfonamide) are new catalysts promoted by one-pot, facile and
four-component synthesis of new substituted 1,4-dihydropyridine derivatives from the
reaction of ammonium acetate, aldehydes and various 1,3-dicarbonyl compounds with
good to high yields at room temperature under mild conditions. All the synthesized
compounds were evaluated for antibacterial and anti-oxidant activities. Antibacterial
activity was determined against four Gram-positive and -negative bacteria, and anti-
oxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl free radical scavenging.
The bioassay results indicated that synthesized 1,4-dihydropyridine derivatives have
effective anti-oxidant and antibacterial functions.
Synthesis and biological evaluation of new series dihydropyridines.
Electronic supplementary material The onlineversion of this article (doi:10.1007/s11164-015-2310-0)
contains supplementary material, which is available to authorized users.
& Ramin Ghorbani-Vaghei
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University,
65174 Hamedan, Iran
Department of Biology, Faculty of Science, Bu-Ali Sina University, 65174 Hamedan, Iran
Res Chem Intermed (2016) 42:4715–4731