Synthesis and antimicrobial evaluation of ferulic acid
Received: 16 February 2013 / Accepted: 6 April 2013 / Published online: 30 April 2013
Ó Springer Science+Business Media Dordrecht 2013
Abstract A series of ferulic acid derivatives (1–38) was synthesized and char-
acterized by physicochemical and spectral means. The synthesized compounds were
evaluated in vitro for their antimicrobial activity against different Gram-positive
and Gram-negative bacterial and fungal strains by the tube dilution method. Results
of antimicrobial screening indicated that compound 1 was the most active antimi-
crobial agent (pMIC
= 1.83 lM/ml).
Keywords Ferulic acid derivatives Á Antibacterial Á Antifungal
The rapid rise in bacterial resistance to traditional antibiotics such as penicillins and
tetracyclines has encouraged a continuing search for new classes of compounds with
novel modes of antibacterial activity. The quinolone antibacterials have emerged as
an area of immense interest because of their broad spectrum of in vitro activity and
their in vivo chemotherapeutic efﬁciency.
The antimicrobial potential of simple organic acids is well established in the
literature, viz. sorbic acid , cinnamic acid , anacardic acid , veratric acid
, myristic acid , caprylic acid , anthranilic acid , and dodecanoic acid .
Literature reports reveal that ferulic acid and its derivatives possess a wide spectrum
of biological activities, such as antioxidant , anticancer , antifungal , anti-
inﬂammatory , and antiviral  activities.
In light of the above-mentioned facts, and in continuation of our research efforts
in the ﬁeld of synthesis, antimicrobial evaluation, and QSAR studies [14–19]we
here report the synthesis and antimicrobial evaluation of ferulic acid derivatives.
A. Khatkar Á A. Nanda Á P. Kumar Á B. Narasimhan (&)
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India
Res Chem Intermed (2015) 41:299–309