Synthesis and antimicrobial activity of some novel ferrocene-based Schiff bases containing a ferrocene unit

Synthesis and antimicrobial activity of some novel ferrocene-based Schiff bases containing a... In the present investigation, a series of ferrocene-based Schiff bases 5a–m were synthesized by the condensation of various chalcones 3a–m with S-benzyl dithiocarbazate in absolute ethanol using catalytic amount of glacial acetic acid, and characterized by element analysis,1H NMR,13C NMR, and IR. The synthesized compounds were screened for their in vitro antimicrobial activity against four bacterias (Staphylococcus aureus ATCC 9144, Bacillus cereus ATCC 11778, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 43288) and two fungals (Aspergillus niger ATCC 9092 and Aspergillus fumigatus ATCC 46645) strains. The Schiff bases 5g, 5h, and 5m against Gram-positive bacterial (E. coli and P. aeruginosa) strains was found to be higher than that for the standard drug. They are potential new drugs in antibacterial activity aspects in further days. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis and antimicrobial activity of some novel ferrocene-based Schiff bases containing a ferrocene unit

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Publisher
Springer Netherlands
Copyright
Copyright © 2011 by Springer Science+Business Media B.V.
Subject
Chemistry; Catalysis; Inorganic Chemistry; Physical Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-011-0440-6
Publisher site
See Article on Publisher Site

Abstract

In the present investigation, a series of ferrocene-based Schiff bases 5a–m were synthesized by the condensation of various chalcones 3a–m with S-benzyl dithiocarbazate in absolute ethanol using catalytic amount of glacial acetic acid, and characterized by element analysis,1H NMR,13C NMR, and IR. The synthesized compounds were screened for their in vitro antimicrobial activity against four bacterias (Staphylococcus aureus ATCC 9144, Bacillus cereus ATCC 11778, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 43288) and two fungals (Aspergillus niger ATCC 9092 and Aspergillus fumigatus ATCC 46645) strains. The Schiff bases 5g, 5h, and 5m against Gram-positive bacterial (E. coli and P. aeruginosa) strains was found to be higher than that for the standard drug. They are potential new drugs in antibacterial activity aspects in further days.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Nov 22, 2011

References

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