Synthesis and antimicrobial activity of p-menth-3-en-1-amine amide derivatives

Synthesis and antimicrobial activity of p-menth-3-en-1-amine amide derivatives A series of p-menth-3-en-1-amine amide derivatives were designed and synthesized. These compounds were identified by FT-IR, ESI+-MS, HRMS, 1H NMR and 13C NMR. Their antimicrobial activity against gram-positive Staphylococcus aureus, gram-negative Klebsiella pneumoniae and Candida albicans was investigated using the microbroth dilution method. The result indicated that some of these newly synthesized compounds had remarkable antimicrobial activity, and the suitable substituent groups were essential for high antimicrobial activity. Compound 5 g displayed the same antimicrobial activity against K. pneumoniae as commercially available antibacterial agents (kanamycin sulfate and rifampicin). The MIC of compound 5 g against K. pneumoniae only was 0.44 µg/mL. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Synthesis and antimicrobial activity of p-menth-3-en-1-amine amide derivatives

Loading next page...
 
/lp/springer_journal/synthesis-and-antimicrobial-activity-of-p-menth-3-en-1-amine-amide-sclLJdCowY
Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2833-z
Publisher site
See Article on Publisher Site

Abstract

A series of p-menth-3-en-1-amine amide derivatives were designed and synthesized. These compounds were identified by FT-IR, ESI+-MS, HRMS, 1H NMR and 13C NMR. Their antimicrobial activity against gram-positive Staphylococcus aureus, gram-negative Klebsiella pneumoniae and Candida albicans was investigated using the microbroth dilution method. The result indicated that some of these newly synthesized compounds had remarkable antimicrobial activity, and the suitable substituent groups were essential for high antimicrobial activity. Compound 5 g displayed the same antimicrobial activity against K. pneumoniae as commercially available antibacterial agents (kanamycin sulfate and rifampicin). The MIC of compound 5 g against K. pneumoniae only was 0.44 µg/mL.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Dec 27, 2016

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off