A series of p-menth-3-en-1-amine amide derivatives were designed and synthesized. These compounds were identified by FT-IR, ESI+-MS, HRMS, 1H NMR and 13C NMR. Their antimicrobial activity against gram-positive Staphylococcus aureus, gram-negative Klebsiella pneumoniae and Candida albicans was investigated using the microbroth dilution method. The result indicated that some of these newly synthesized compounds had remarkable antimicrobial activity, and the suitable substituent groups were essential for high antimicrobial activity. Compound 5 g displayed the same antimicrobial activity against K. pneumoniae as commercially available antibacterial agents (kanamycin sulfate and rifampicin). The MIC of compound 5 g against K. pneumoniae only was 0.44 µg/mL.
Research on Chemical Intermediates – Springer Journals
Published: Dec 27, 2016
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