Synthesis and anticancer evaluation of some fused coumarino-[4,3-d]-pyrimidine derivatives

Synthesis and anticancer evaluation of some fused coumarino-[4,3-d]-pyrimidine derivatives 7- or 9-substituted-2-amino-4-hydroxy-7-methoxy-5H-chromeno-[4,3-d]-pyrimidine-5-one, 3a,b, were prepared via cyclocondensation of 6- or 8-substituted-3-ethoxycarbonyl coumarin, 2, with guanidine hydrochloride in presence of anhydrous potassium carbonate. Acetylation and alkylation of compounds with acetic anhydride and ω-bromomethyl aryl ketones yielded the corresponding N-acetyl derivatives, 4a,b, and 8- or 10-substituted-5-hydroxy-1-p-tolyl-6-H-chromeno[3,4-e] imidazo[1,2-a] pyrimidine-6-one, 5a,b,. Treatment of compound 3a with ethylchloroacetate and methyl acrylate afforded the corresponding benzopyrano-[4,3-d]-imidazolidino-[2,1-b]-pyrimidine, 6, and benzopyrano-[4,3-d]-pyrimidino-[2,1-b]-pyrimidine, 7, respectively. Some of the new compounds were evaluated for cytotoxicity activity against a hepatocellular carcinoma cell line. Research on Chemical Intermediates Springer Journals

Synthesis and anticancer evaluation of some fused coumarino-[4,3-d]-pyrimidine derivatives

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Springer Netherlands
Copyright © 2013 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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