In the search for new benzimidazole derivatives with high antibacterial activity and for which bacterial resistance is low, novel ethyl 2-(alkoxyimino)-2-[1-(4-morpholinocarbonylmethyl)-1H-benzimidazol-2-yl]acetates have been synthesized by multi-step reactions and characterized by 1H NMR, IR, and ESI–MS analysis. The compounds were evaluated for in-vitro antibacterial activity against Escherichia coli and Staphylococcus aureus. The results revealed that four of the compounds had excellent bioactivity against S. aureus, with IC50 values of 12.72–26.58 μg/mL, even better than that of the control agent (levofloxacin hydrochloride).
Research on Chemical Intermediates – Springer Journals
Published: Oct 16, 2013
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