A novel complex [Cd(Phen)2(Pzdc)] · 7.5(H2O) (I), where Phen = 1,10-phenanthroline, Pzdc = 2,3-pyrazinedicarboxylic acid, has been synthesized under room temperature conditions and characterized by IR spectroscopy, elemental analysis, and X-ray single-crystal structure analysis (CIF file CCDC no. 1023407). Its mode of interaction with fish sperm DNA (FS-DNA) have been determined by fluorescence. Gel electrophoresis assay demonstrates the ability of complex I to cleave the HL-60 DNA. Furthermore, apoptosis assay shows treatment with complex results in morphological changes of cancer cell lines. The results induce apoptosis in JEKO cells.
Russian Journal of Coordination Chemistry – Springer Journals
Published: Mar 5, 2015
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