Syntheses, structures, characterization, and bioactivities of new Cd(II) complex of 2,3-pyrazinedicarboxylate with 1,10-phenanthroline

Syntheses, structures, characterization, and bioactivities of new Cd(II) complex of... A novel complex [Cd(Phen)2(Pzdc)] · 7.5(H2O) (I), where Phen = 1,10-phenanthroline, Pzdc = 2,3-pyrazinedicarboxylic acid, has been synthesized under room temperature conditions and characterized by IR spectroscopy, elemental analysis, and X-ray single-crystal structure analysis (CIF file CCDC no. 1023407). Its mode of interaction with fish sperm DNA (FS-DNA) have been determined by fluorescence. Gel electrophoresis assay demonstrates the ability of complex I to cleave the HL-60 DNA. Furthermore, apoptosis assay shows treatment with complex results in morphological changes of cancer cell lines. The results induce apoptosis in JEKO cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Coordination Chemistry Springer Journals

Syntheses, structures, characterization, and bioactivities of new Cd(II) complex of 2,3-pyrazinedicarboxylate with 1,10-phenanthroline

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Publisher
Pleiades Publishing
Copyright
Copyright © 2015 by Pleiades Publishing, Ltd.
Subject
Chemistry; Physical Chemistry; Inorganic Chemistry
ISSN
1070-3284
eISSN
1608-3318
D.O.I.
10.1134/S1070328415020104
Publisher site
See Article on Publisher Site

Abstract

A novel complex [Cd(Phen)2(Pzdc)] · 7.5(H2O) (I), where Phen = 1,10-phenanthroline, Pzdc = 2,3-pyrazinedicarboxylic acid, has been synthesized under room temperature conditions and characterized by IR spectroscopy, elemental analysis, and X-ray single-crystal structure analysis (CIF file CCDC no. 1023407). Its mode of interaction with fish sperm DNA (FS-DNA) have been determined by fluorescence. Gel electrophoresis assay demonstrates the ability of complex I to cleave the HL-60 DNA. Furthermore, apoptosis assay shows treatment with complex results in morphological changes of cancer cell lines. The results induce apoptosis in JEKO cells.

Journal

Russian Journal of Coordination ChemistrySpringer Journals

Published: Mar 5, 2015

References

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