Syntheses, structures, characterization, and bioactivities of new Cd(II) complex of 2,3-pyrazinedicarboxylate with 1,10-phenanthroline

Syntheses, structures, characterization, and bioactivities of new Cd(II) complex of... A novel complex [Cd(Phen)2(Pzdc)] · 7.5(H2O) (I), where Phen = 1,10-phenanthroline, Pzdc = 2,3-pyrazinedicarboxylic acid, has been synthesized under room temperature conditions and characterized by IR spectroscopy, elemental analysis, and X-ray single-crystal structure analysis (CIF file CCDC no. 1023407). Its mode of interaction with fish sperm DNA (FS-DNA) have been determined by fluorescence. Gel electrophoresis assay demonstrates the ability of complex I to cleave the HL-60 DNA. Furthermore, apoptosis assay shows treatment with complex results in morphological changes of cancer cell lines. The results induce apoptosis in JEKO cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Coordination Chemistry Springer Journals

Syntheses, structures, characterization, and bioactivities of new Cd(II) complex of 2,3-pyrazinedicarboxylate with 1,10-phenanthroline

Loading next page...
 
/lp/springer_journal/syntheses-structures-characterization-and-bioactivities-of-new-cd-ii-hmNXBtRiL0
Publisher
Springer Journals
Copyright
Copyright © 2015 by Pleiades Publishing, Ltd.
Subject
Chemistry; Physical Chemistry; Inorganic Chemistry
ISSN
1070-3284
eISSN
1608-3318
D.O.I.
10.1134/S1070328415020104
Publisher site
See Article on Publisher Site

Abstract

A novel complex [Cd(Phen)2(Pzdc)] · 7.5(H2O) (I), where Phen = 1,10-phenanthroline, Pzdc = 2,3-pyrazinedicarboxylic acid, has been synthesized under room temperature conditions and characterized by IR spectroscopy, elemental analysis, and X-ray single-crystal structure analysis (CIF file CCDC no. 1023407). Its mode of interaction with fish sperm DNA (FS-DNA) have been determined by fluorescence. Gel electrophoresis assay demonstrates the ability of complex I to cleave the HL-60 DNA. Furthermore, apoptosis assay shows treatment with complex results in morphological changes of cancer cell lines. The results induce apoptosis in JEKO cells.

Journal

Russian Journal of Coordination ChemistrySpringer Journals

Published: Mar 5, 2015

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off