Two types of valproamide dipeptides, i.e., valproic acid (VPA)-Tyr-Tyr and VPA-His-His, were synthesized via Fmoc solid-phase peptide synthesis, purified via reversed-phase HPLC, and characterized via 1H, 13C NMR and ESI–MS to promote the interaction of valproic acid derivative with biological molecular. The interactions of VPA-Tyr-Tyr and VPA-His-His with DNA were investigated via UV–Vis absorption spectroscopy, fluorescence spectroscopy, and gel electrophoresis. The results showed that both VPA-Tyr-Tyr and VPA-His-His interacted with ctDNA through the groove binding mode and exhibited higher affinity for ctDNA compared with free VPA. Therefore, the valpromide derivatives modified by dipeptides have significant practical value in future studies.
Research on Chemical Intermediates – Springer Journals
Published: Jan 7, 2015
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